Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Correlations02:20

Correlations

35.9K
Correlation means that there is a relationship between two or more variables (such as ice cream consumption and crime), but this relationship does not necessarily imply cause and effect. When two variables are correlated, it simply means that as one variable changes, so does the other. We can measure correlation by calculating a statistic known as a correlation coefficient. A correlation coefficient is a number from -1 to +1 that indicates the strength and direction of the relationship between...
35.9K
Correlation and Causation01:27

Correlation and Causation

42.7K
Statistical tests can calculate whether there is a relationship, or correlation, between independent and dependent variables. An indirect relationship of the variables signifies a correlation, while a direct relationship shows causation. If it is determined that no connection exists between the variables, then the correlation is a coincidence.
Correlation versus Causation
If the dependent variable increases or decreases when the independent variable increases, there is a positive or negative...
42.7K
Assessing Body Temperature - Rectal01:27

Assessing Body Temperature - Rectal

12.1K
Rectal temperature measurement is considered the most precise method for assessing core body temperature and typically registers higher than oral temperature. For adults, the rectal thermometer should be inserted 1 to 1.5 inches into the rectum to obtain the most accurate reading.
Follow these steps for rectal temperature assessment:
Step 1: Perform hand hygiene and don clean gloves to prevent cross-infection.
Step 2: Position the patient in a side-lying position to better visualize the rectal...
12.1K
Correlation01:09

Correlation

15.1K
In statistics, two variables are said to be correlated if the values of one variable are associated with the other variable. Depending on the relationship between two variables, correlation can be of three types– positive correlation, negative correlation, and zero correlation.
Two variables, for example, a and b, are said to be positively correlated if both variables move in the same direction. In other words, a positive correlation exists between two variables, a and b, if:
15.1K
Density00:56

Density

19.9K
Density is an important characteristic of substances, crucial in determining whether an object sinks or floats in a fluid. Its SI unit is kg/m3, and its cgs unit is g/cm3. The density of an object helps in identifying its composition, and also reveals information about the phase of the matter and its substructure. The densities of liquids and solids are roughly comparable, consistent with the fact that their atoms are in close contact. However, gases have much lower densities than liquids and...
19.9K
Current Density01:21

Current Density

5.1K
The total amount of current flowing through one unit value of a cross-sectional area is referred to as current density. If the current flow is uniform, the amount of current flowing through a conductor is the same at all points along the conductor, even if the conductor area varies. The current density consists of the local magnitude and direction of the charge flow, which varies from point to point. Current density is measured in amperes per meter square, and direction is defined as the net...
5.1K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Mental health management in the context of TB care in the WHO European Region: a consensus statement.

IJTLD open·2026
Same author

RENEB Inter-Laboratory Comparison 2021: Inter-Assay Comparison of Eight Dosimetry Assays.

Radiation research·2023
Same author

[Perspectives of patients with Duchenne muscular dystrophy: A focal group to improve healthcare quality].

Journal of healthcare quality research·2020
Same author

Before and After Treatment Quantitative Assessment of Hepatic Steatosis in a Romanian Population Using Magnetic Resonance Liver Spectroscopy.

Current health sciences journal·2020
Same author

Importance of Rehabilitation in Primary Knee Osteoarthritis.

Current health sciences journal·2019
Same author

Statistical Study of Dental Changes in Patients Diagnosed with Diabetes Mellitus.

Current health sciences journal·2019

Related Experiment Video

Updated: Feb 3, 2026

Y-90 Radioembolization and PD-1 Inhibitor as Neoadjuvant Treatment in Hepatocellular Carcinoma
09:11

Y-90 Radioembolization and PD-1 Inhibitor as Neoadjuvant Treatment in Hepatocellular Carcinoma

Published on: May 24, 2024

1.2K

Correlations Between Intratumoral Microvessel Density and Histopathological Type or Neoadjuvant Radiotherapy for

T Dumitrescu1, C D Uscatu2, D O Alexandru3

  • 1Department of Surgery, University of Medicine and Pharmacy of Craiova, Romania.

Current Health Sciences Journal
|October 27, 2018
PubMed
Summary

Intratumoral microvessel density is higher in non-irradiated rectal tumors and adenocarcinomas. Neoadjuvant radiotherapy reduces angiogenic activity, offering prognostic value for rectal cancer.

Keywords:
CD105CD31CD34histopathologicalradiotherapyrectal cancer

More Related Videos

Optical Frequency Domain Imaging of Ex vivo Pulmonary Resection Specimens: Obtaining One to One Image to Histopathology Correlation
14:21

Optical Frequency Domain Imaging of Ex vivo Pulmonary Resection Specimens: Obtaining One to One Image to Histopathology Correlation

Published on: January 22, 2013

14.6K
Voluntary Breath-hold Technique for Reducing Heart Dose in Left Breast Radiotherapy
11:38

Voluntary Breath-hold Technique for Reducing Heart Dose in Left Breast Radiotherapy

Published on: July 3, 2014

47.5K

Related Experiment Videos

Last Updated: Feb 3, 2026

Y-90 Radioembolization and PD-1 Inhibitor as Neoadjuvant Treatment in Hepatocellular Carcinoma
09:11

Y-90 Radioembolization and PD-1 Inhibitor as Neoadjuvant Treatment in Hepatocellular Carcinoma

Published on: May 24, 2024

1.2K
Optical Frequency Domain Imaging of Ex vivo Pulmonary Resection Specimens: Obtaining One to One Image to Histopathology Correlation
14:21

Optical Frequency Domain Imaging of Ex vivo Pulmonary Resection Specimens: Obtaining One to One Image to Histopathology Correlation

Published on: January 22, 2013

14.6K
Voluntary Breath-hold Technique for Reducing Heart Dose in Left Breast Radiotherapy
11:38

Voluntary Breath-hold Technique for Reducing Heart Dose in Left Breast Radiotherapy

Published on: July 3, 2014

47.5K

Area of Science:

  • Oncology
  • Pathology
  • Angiogenesis Research

Background:

  • Rectal carcinoma exhibits diverse histopathological subtypes, including adenocarcinoma and mucinous carcinoma.
  • Neoadjuvant radiotherapy is a common treatment modality for rectal cancer, potentially influencing tumor microenvironment.
  • Intratumoral microvessel density (IMD) is a key indicator of tumor angiogenesis and has prognostic implications.

Purpose of the Study:

  • To evaluate IMD in rectal carcinoma based on histopathological type (adenocarcinoma vs. mucinous carcinoma).
  • To assess the impact of neoadjuvant radiotherapy on IMD in rectal cancer.
  • To determine statistical correlations between IMD, histopathology, and radiotherapy status.

Main Methods:

  • Prospective study involving 25 rectal carcinoma samples.
  • Standard immunohistochemistry techniques utilized CD34, CD31, and CD105 antibodies.
  • Quantification of intratumoral microvessel density.

Main Results:

  • Higher IMD observed in adenocarcinomas compared to mucinous carcinomas.
  • Significantly higher IMD in non-irradiated rectal tumors versus irradiated tumors (p<0.05 for CD31 and CD105).
  • CD34 staining showed a non-significant trend towards higher IMD in non-irradiated tumors.

Conclusions:

  • Non-irradiated rectal tumors and adenocarcinomas exhibit higher IMD.
  • Neoadjuvant radiotherapy demonstrates a beneficial effect in decreasing angiogenic activity in rectal cancer.
  • IMD serves as a significant prognostic marker in rectal cancer, influenced by treatment and histology.