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Investigating von Willebrand Factor Pathophysiology Using a Flow Chamber Model of von Willebrand Factor-platelet String Formation
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Von Willebrand factor contribution to pathophysiology outside of von Willebrand disease

Anahita Mojiri1, Parnian Alavi1, Nadia Jahroudi1

  • 1Department of Medicine, University of Alberta, Edmonton, Alberta, Canada.

Microcirculation (New York, N.Y. : 1994)
|October 27, 2018
PubMed

VWF is a procoagulant protein that plays a central role in the initiation of platelets aggregate formation and thrombosis. While von Willebrand disease has long been known to result from qualitative and quantitative deficiencies of VWF, it is recently that contribution of elevated levels of VWF to various pathological conditions including thrombosis, inflammation, angiogenesis, and cancer metastasis has been appreciated. Here, we discuss contribution of elevated levels of VWF to various thrombotic and nonthrombotic pathological conditions.

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