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Monitoring of Nanodrug Accumulation in Murine Breast Cancer Metastases
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VE-Albumin Core-Shell Nanoparticles for Paclitaxel Delivery to Treat MDR Breast Cancer.

Bo Tang1, Yu Qian2, Yi Gou3

  • 1School of Pharmacy, Nantong University, 19 Qixiu Road, Nantong 226001, Jiangsu, China. tangbo@ntu.edu.cn.

Molecules (Basel, Switzerland)
|October 28, 2018
PubMed
Summary

Vitamin E-Albumin nanoparticles effectively deliver paclitaxel, enhancing chemotherapy for multi-drug resistant breast cancer. This novel nanocarrier improves drug uptake and anti-cancer efficacy in preclinical models.

Keywords:
Vitamin Ealbuminbreast cancercore-shell nanoparticlesmulti-drug resistancepaclitaxel

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Area of Science:

  • Nanotechnology
  • Materials Science
  • Oncology

Background:

  • Multi-drug resistance (MDR) significantly compromises chemotherapy effectiveness in cancer treatment.
  • Paclitaxel (PTX) is a key chemotherapeutic agent often hindered by MDR.
  • Novel drug delivery systems are crucial for overcoming MDR and improving therapeutic outcomes.

Purpose of the Study:

  • To develop Vitamin E (VE)-Albumin core-shell nanoparticles for enhanced paclitaxel (PTX) delivery.
  • To evaluate the efficacy of PTX-loaded VE-Albumin nanoparticles (PTX-VE NPs) in a multi-drug resistant (MDR) breast cancer model.

Main Methods:

  • Fabrication and characterization of PTX-loaded VE-Albumin core-shell nanoparticles (PTX-VE NPs).
  • In vitro studies including drug release, docking analysis, confocal microscopy for cellular uptake, and cytotoxicity assays.
  • In vivo evaluation of anti-cancer efficacy using an MCF-7/ADR tumor xenograft model.

Main Results:

  • PTX-VE NPs exhibited optimal particle size (~100 nm), high drug entrapment (95.7%), and loading capacity (12.5%) with sustained release.
  • Docking studies confirmed hydrophobic interactions and hydrogen bonds in PTX-VE NP formation.
  • PTX-VE NPs significantly enhanced PTX cellular uptake and cytotoxicity in MCF-7/ADR cells compared to PTX NPs.
  • In vivo studies demonstrated superior anti-cancer efficacy of PTX-VE NPs over PTX NPs and PTX solutions in the tumor xenograft model.

Conclusions:

  • VE-Albumin core-shell nanoparticles represent a promising nanocarrier for paclitaxel delivery.
  • This nanocarrier system effectively overcomes multi-drug resistance in breast cancer models.
  • The developed nanoparticles hold potential for improving chemotherapeutic efficacy in MDR cancers.