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Related Concept Videos

Anatomy of the Intestines01:23

Anatomy of the Intestines

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Although digestion of proteins, carbohydrates, and lipids may begin in the stomach, it is completed in the intestine. The absorption of nutrients, water, and electrolytes from food and drink also occurs in the intestine. The intestines can be divided into two structurally distinct organs—the small and large intestines.
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Permeability of Concrete01:25

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Permeability in the context of concrete refers to how easily liquids or gases can pass through the material. This quality is crucial for assessing the water-tightness and durability of concrete structures and their resistance to chemical attacks. Concrete permeability can be determined through comparative laboratory tests. These tests typically involve sealing a concrete specimen from the sides, applying water pressure to the top surface with pressure, and measuring the amount of water passing...
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Protein Complex Assembly02:41

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Proteins can form homomeric complexes with another unit of the same protein or heteromeric complexes with different types.  Most protein complexes self-assemble spontaneously via ordered pathways, while some proteins need assembly factors that guide their proper assembly. Despite the crowded intracellular environment, proteins usually interact with their correct partners and form functional complexes.
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Magnetic Susceptibility and Permeability01:31

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In linear magnetic materials, like paramagnets and diamagnets, magnetization is proportional to the magnetic field intensity. The constant of proportionality, a dimensionless number, is called magnetic susceptibility. The value of the susceptibility depends on the type of material.
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Small Intestine01:15

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The small intestine is primarily responsible for digestion and nutrient absorption. It spans from the pyloric sphincter to the ileocecal valve and connects to the large intestine.
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Large Intestine01:09

Large Intestine

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The large intestine is divided into three main regions: the cecum, colon, and rectum. Extending from the ileocecal valve to the anus, it frames the small intestine on three sides.
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Related Experiment Video

Updated: Feb 3, 2026

Measuring the Effects of Bacteria and Chemicals on the Intestinal Permeability of Caenorhabditis elegans
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Nintedanib-cyclodextrin complex to improve bio-activity and intestinal permeability.

Bhuvaneshwar Vaidya1, Snehal K Shukla2, Srikanth Kolluru1

  • 1School of Pharmacy, Keck Graduate Institute, Claremont, CA 91711, United States.

Carbohydrate Polymers
|October 28, 2018
PubMed
Summary

Cyclodextrin complexation enhanced nintedanib

Keywords:
CyclodextrinIntestinal permeabilityNintedanibPulmonary fibrosisp-Glycoprotein efflux

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Area of Science:

  • Pharmaceutical Sciences
  • Drug Delivery Systems
  • Biotechnology

Background:

  • Nintedanib, an anti-fibrotic drug, faces challenges with bioavailability and intestinal transport.
  • P-glycoprotein (p-gp) efflux limits nintedanib's therapeutic efficacy.
  • Cyclodextrins offer potential for improving drug properties.

Purpose of the Study:

  • To prepare and characterize a cyclodextrin complex of nintedanib.
  • To evaluate the impact of complexation on nintedanib's stability, bioactivity, and intestinal permeability.
  • To investigate the effect of complexation on p-glycoprotein efflux.

Main Methods:

  • Solubility studies and molecular modeling guided the selection of sulfobutyl ether β-cyclodextrin (SBE-β-CD).
  • Complexation was confirmed using Fourier-transform infrared spectroscopy (FTIR), 1H Nuclear Magnetic Resonance (NMR), Differential Scanning Calorimetry (DSC), and X-ray Diffraction (XRD).
  • In vitro bioactivity was assessed in lung fibroblast cells (WI-38), and permeability studies utilized an epiIntestinal tissue model.

Main Results:

  • Cyclodextrin complexation enhanced nintedanib's stability in various physiological fluids.
  • The complex demonstrated improved anti-proliferative activity, collagen deposition modulation, and cell migration effects.
  • In vitro studies showed increased nintedanib transport across the intestinal membrane and reduced p-gp efflux ratio.

Conclusions:

  • SBE-β-CD successfully formed an inclusion complex with nintedanib.
  • Cyclodextrin complexation significantly improved nintedanib's stability and bioactivity.
  • Complexation enhanced intestinal transport and mitigated p-gp efflux, offering a promising strategy for nintedanib delivery.