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Neuroborreliosis.

John J Halperin1

  • 1Department of Neurosciences, Overlook Medical Center, 99 Beauvoir Avenue, Summit, NJ 07902, USA; Sidney Kimmel Medical College, Thomas Jefferson University, 1025 Walnut Street, Philadelphia, PA 19107, USA.

Neurologic Clinics
|October 28, 2018
PubMed
Summary
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Neurologic Lyme disease, caused by Borrelia bacteria, presents with meningitis and nerve inflammation. Diagnosis relies on exposure, rash, or positive serologic tests, with cerebrospinal fluid analysis confirming central nervous system infection.

Area of Science:

  • Neurology
  • Infectious Diseases
  • Immunology

Background:

  • Lyme disease, caused by Borrelia burgdorferi sensu lato complex (including Borrelia garinii and Borrelia afzelii), can affect the nervous system.
  • Neurologic manifestations are common, but parenchymal central nervous system (CNS) infection is rare.

Purpose of the Study:

  • To describe the spectrum of neurologic manifestations of Lyme disease.
  • To outline diagnostic criteria for neuroborreliosis.

Main Methods:

  • Review of clinical presentations and diagnostic findings in neuroborreliosis.
  • Analysis of cerebrospinal fluid (CSF) findings, including pleocytosis and intrathecal antibody production.
  • Evaluation of serologic testing and clinical signs like erythema migrans for diagnosis.
Keywords:
Borrelia burgdorferiBorreliellaDiagnosisLymeMononeuropathy multiplexNeuroborreliosisRadiculoneuritisTreatment

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Main Results:

  • Common neurologic symptoms include lymphocytic meningitis, cranial neuritis, and radiculoneuritis.
  • Neurobehavioral changes are frequent but not indicative of CNS infection.
  • Diagnosis is supported by a history of exposure, erythema migrans, or positive two-tiered serologic testing.
  • Cerebrospinal fluid analysis often reveals pleocytosis and specific antibody production within the CNS.

Conclusions:

  • Neurologic Lyme disease manifestations are generally consistent across Borrelia species.
  • Accurate diagnosis requires a combination of clinical suspicion, exposure history, and laboratory confirmation.
  • Distinguishing CNS infection from peripheral nervous system involvement is crucial for appropriate management.