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Diagnostic histochemistry: A historical perspective
1Divisions of Surgical Pathology & Cytopathology and Autopsy Pathology, University of Virginia Medical Center, 1215 Lee St., Charlottesville, VA 22908-0214, USA.
Abstract:
Histochemistry has a history which, in some ways, goes back to ancient times. The desire for humans to understand the workings of their bodies, and the roles that various chemicals have in them, is long-standing. This review considers the evolution of histochemistry and cytochemistry as scientific disciplines, culminating in the pairing of those techniques with basic biochemistry. They have served as the bases for a synthesis of microscopy, chemistry, immunology, and molecular biology, particularly in the practice of anatomic pathology.
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