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Gold core-satellite nanostructure linked by oligonucleotides for detection of glutathione with LSPR scattering
Ying-Bo Liu1, Ting-Ting Zhai2, Yan-Yan Liang1
1School of Chemistry and Chemical Engineering, Shandong University of Technology, Zibo 255000, China.
Abstract:
We demonstrated a sensitive method for detection of glutathione (GSH) based on LSPR scattering spectrum using gold core-satellite nanostructure linked by T-Hg2+-T base pair. The core-satellite assembly caused coupling between plasmonic nanoparticles, which inducing distinct change of LSPR peak wavelength. As the interaction between Hg2+ and GSH, the core-satellite nanostructure would be disassembled, which accompanied with spectral blue-shift of the scattering spectrum. By using this method, GSH could be quantitatively detected, and the detection limits can reach to 0.1 µM.
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