Remarkable Enhancement in Boron Uptake Within Glioblastoma Cells With Carboranyl-Indole Carboxamides
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Updated: Feb 3, 2026

Live Imaging of Microtubule Dynamics in Glioblastoma Cells Invading the Zebrafish Brain
Published on: July 29, 2022
Rajeshwar Narlawar1, Christopher J D Austin1, Jan Kahlert1
1School of Chemistry, The University of Sydney, Sydney, NSW, 2006, Australia.
Abstract:
Novel boron-rich, carboranyl-indole carboxamide ligands were prepared and found to effectively target the 18 kDa translocator protein (TSPO), an upregulated mitochondrial membrane-bound protein which has been observed in variety of tumor cell lines and its expression appears to be proportional to the degree of tumorigenicity, emphasizing a key role in cancer cell proliferation. Both boronated compounds displayed remarkably high affinities for the TSPO. In addition, the in vitro uptake of these compounds into T98G human glioma cells was found to be 25- to 100-fold greater than that of clinical boron neutron capture therapy (BNCT) agents.
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