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Related Experiment Video

Updated: Feb 3, 2026

A Microphysiologic Platform for Human Fat: Sandwiched White Adipose Tissue
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Human White Adipose Tissue Metabolome: Current Perspective.

Jan Kučera1, Zdeněk Spáčil1, David Friedecký2

  • 1Research Centre for Toxic Compounds in the Environment (RECETOX), Faculty of Science, Masaryk University, Brno, Czech Republic.

Obesity (Silver Spring, Md.)
|October 29, 2018
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Summary

Adipose tissue is a metabolically active organ. Metabolomics analysis of adipose tissue and biological fluids can identify biomarkers for obesity-related metabolic disorders.

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Area of Science:

  • Biochemistry
  • Metabolomics
  • Endocrinology

Background:

  • Adipose tissue, once considered inert, is now recognized as a metabolically active organ impacting human health.
  • The study of adipose tissue metabolites is crucial for understanding metabolic regulation.
  • Mass spectrometry-based metabolomics offers powerful tools for analyzing complex biological samples like adipose tissue.

Purpose of the Study:

  • To review the current state of metabolomics approaches for studying white adipose tissue and obesity.
  • To highlight metabolites as potential biomarkers for obesity-related metabolic alterations.
  • To provide an overview of basic principles and metabolite groups relevant to adipose tissue.

Main Methods:

  • Review of current literature on metabolomics in adipose tissue research.
  • Analysis of metabolites in white adipose tissue and biological fluids.
  • Focus on mass spectrometry-based metabolomics techniques.

Main Results:

  • Metabolomics enables the investigation of distinct metabolites in adipose tissue.
  • Identification of differences in metabolic profiles between physiological and pathophysiological states.
  • Potential for discovering novel diagnostic and prognostic biomarkers for metabolic disorders.

Conclusions:

  • Metabolomics is a key tool for understanding adipose tissue function in obesity.
  • Specific metabolites can serve as reliable biomarkers for metabolic alterations.
  • This field offers insights into monitoring and managing obesity-related metabolic disorders.