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Glucose Sensing Using Surface-Enhanced Raman-Mode Constraining.

Daejong Yang1,2, Sajjad Afroosheh3, Jeong Oen Lee4

  • 1Department of Medical Engineering , California Institute of Technology , Pasadena , California 91125 , United States.

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Summary
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This study presents a new method for continuous glucose monitoring using surface-enhanced Raman scattering (SERS) with mercaptophenylboronic acid (MPBA). The SERS-based sensor offers fast, reversible, and stable glucose level detection for diabetes management.

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Area of Science:

  • Biomedical Engineering
  • Analytical Chemistry
  • Materials Science

Background:

  • Diabetes mellitus requires constant glucose monitoring to prevent complications.
  • Current continuous glucose monitoring (CGM) methods have limitations.
  • Developing novel, stable, and accurate glucose sensors is crucial.

Purpose of the Study:

  • To demonstrate a fast and continuous glucose sensing method using surface-enhanced Raman scattering (SERS).
  • To investigate the mechanism of glucose detection via mercaptophenylboronic acid (MPBA) interaction.
  • To assess the feasibility of SERS implants for intraocular glucose monitoring.

Main Methods:

  • Utilized mercaptophenylboronic acid (MPBA) functionalized SERS substrates.
  • Tracked glucose-induced shifts in SERS emission peaks (1071 cm⁻¹ to 1084 cm⁻¹).
  • Performed numerical simulations to verify the sensing mechanism.
  • Tested MPBA-coated substrates for stability over 30 days.
  • Demonstrated intraocular glucose measurements using miniaturized SERS implants in ex vivo rabbit eyes.

Main Results:

  • Achieved fast and continuous glucose sensing in the physiological range (0.1–30 mM).
  • Observed a reversible shift in SERS peaks upon glucose binding to MPBA.
  • Demonstrated stable sensor performance over a 30-day period.
  • Intraocular glucose measurements in rabbit eyes showed high accuracy (±0.5 mM) compared to commercial sensors.

Conclusions:

  • The MPBA-based SERS approach provides a promising platform for long-term continuous glucose monitoring.
  • The reversible nature and stability of the sensor are advantageous for practical applications.
  • Miniaturized SERS implants show potential for in vivo glucose sensing, including intraocular measurements.