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Spinal Tuberculosis - Directly Observed Treatment and Short Course or Daily Anti Tubercular Therapy -Are We Over
Ravinder Kumar Banga1, Jagdeep Singh2, Anshul Dahuja2
1Department of Orthopaedics, Government Medical College, Patiala, Punjab, India.
The Open Orthopaedics Journal
|October 30, 2018
Summary
Directly Observed Treatment and Short Course (DOTS) and Daily Anti Tubercular Therapy (ATT) showed comparable effectiveness in treating spinal tuberculosis without neurological deficits. Further research is needed to evaluate efficacy in patients with neurological involvement.
Area of Science:
- Orthopedics
- Infectious Diseases
- Public Health
Background:
- Spinal tuberculosis is a significant cause of morbidity and mortality in India.
- Optimal management strategies, including drug regimens and treatment duration, remain debated.
Purpose of the Study:
- To compare the effectiveness of Directly Observed Treatment and Short Course (DOTS) versus Daily Anti Tubercular Therapy (ATT) for spinal tuberculosis.
- To assess treatment outcomes in patients without neurological deficits.
Main Methods:
- Prospective randomized controlled trial involving 30 patients with spinal tuberculosis.
- Patients were randomly assigned to either DOTS or Daily ATT groups (15 each).
- Outcomes were evaluated based on clinical, radiological, and Erythrocyte Sedimentation Rate (ESR) parameters.
Main Results:
- Both DOTS and Daily ATT demonstrated significant pain reduction (89.39% and 91.73% change, respectively) with no significant difference (p > 0.05).
- Radiological recovery was comparable between the two treatment groups after 1.5 years (p > 0.05).
- Mean ESR score changes were similar for both DOTS and Daily ATT (74.57% and 75.69% change, respectively), with no significant difference (p > 0.05).
Conclusions:
- Directly Observed Treatment and Short Course (DOTS) is an effective management strategy for spinal tuberculosis without neurological deficits.
- The efficacy of DOTS in patients with neurological deficits requires further investigation.
Keywords:
ATTDOTSErythrocyte Sedimentation Rate values (ESR)Spinal TuberculosisTherapyVisual Analogue Scale (VAS)More Related Videos
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