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Updated: Feb 3, 2026
08:42
Establishment of Gastric Cancer Patient-derived Xenograft Models and Primary Cell Lines
Published on: July 19, 2019
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[Progress in conversion therapy for originally unresectable gastric cancer]
Xinhua Chen1, Zhousheng Lin1, Yuehong Chen1
1Department of General Surgery Nanfang Hospital, Southern Medical University, Guangzhou 510515, China.
Summary
Conversion therapy aims to cure unresectable gastric cancer. Research is ongoing to identify suitable patients for this approach, focusing on chemotherapy response and surgical outcomes for better survival.
Area of Science:
- Oncology
- Surgical Oncology
- Gastroenterology
Background:
- Conversion therapy is explored for initially unresectable, late-stage gastric cancer.
- It aims for radical cure, improved survival, and recurrence-free survival post-chemotherapy.
- Current research suggests chemotherapy response and R0 resection are linked to better outcomes.
Purpose of the Study:
- To review the current research progress on conversion therapy for originally unresectable late-stage gastric cancer.
- To highlight the need for better screening criteria and clinical evidence.
- To discuss the potential benefits and challenges of conversion therapy.
Main Methods:
- Review of existing clinical research and literature on conversion therapy for gastric cancer.
- Analysis of factors associated with favorable prognosis in conversion therapy.
- Examination of chemotherapy regimens and their efficacy.
Main Results:
- Paclitaxel-based triplet chemotherapy shows promise for increasing remission and R0 resection rates.
- Patient selection remains critical due to tumor heterogeneity.
- Lymphatic metastasis appears more responsive than peritoneal metastasis.
Conclusions:
- Conversion therapy holds potential for selected late-stage gastric cancer patients.
- Further high-level clinical evidence and expert consensus are urgently needed.
- Clinical trials are essential to refine patient selection and optimize treatment strategies.
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