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Application of Immuno-PET in Antibody-Drug Conjugate Development

Kendra S Carmon1, Ali Azhdarinia1

  • 11 Institute of Molecular Medicine, McGovern Medical School, The University of Texas Health Science Center at Houston, Houston, TX, USA.

Molecular Imaging
|October 30, 2018
PubMed

Insights

Zirconium-89 (89Zr)-immuno-PET imaging helps select cancer patients for targeted therapies. This method predicts treatment efficacy and toxicity for antibody-drug conjugates (ADCs), guiding individualized cancer care.

Area of Science:

  • Nuclear Medicine
  • Oncology
  • Pharmacology

Background:

  • Targeted cancer therapies show promise, especially with patient selection tools.
  • Identifying likely responders minimizes ineffective treatments and clarifies drug effects.
  • Positron emission tomography (PET) with zirconium-89 (89Zr)-labeled monoclonal antibodies (immuno-PET) can measure target expression and drug delivery.

Purpose of the Study:

  • To review the use of 89Zr-immuno-PET as a companion diagnostic for antibody-drug conjugate (ADC) development.
  • To discuss the potential of 89Zr-immuno-PET in future clinical trials with novel ADCs.
  • To explore how 89Zr-immuno-PET can guide patient selection and optimize dosing regimens for ADCs.

Main Methods:

  • Review of current literature on 89Zr-immuno-PET applications in oncology.
  • Analysis of how immuno-PET assesses biodistribution, pharmacokinetics, and tumor targeting of antibodies and ADCs.
  • Discussion of predictive value of 89Zr-immuno-PET for ADC toxicity and efficacy.

Main Results:

  • 89Zr-immuno-PET is emerging as a companion diagnostic for ADC development.
  • The technique can evaluate whole-body biodistribution and tumor targeting of ADCs.
  • Immuno-PET has the potential to predict ADC efficacy and toxicity.

Conclusions:

  • 89Zr-immuno-PET can guide individualized cancer treatment by predicting response to targeted therapies like ADCs.
  • Future clinical trials can leverage 89Zr-immuno-PET to select patients most likely to benefit from novel ADCs.
  • This imaging modality may improve ADC dosing strategies and enhance treatment outcomes.
Keywords:
antibody–drug conjugatescancercompanion diagnosticsimmuno-PETmolecular imaging

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