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Noninvasive, High-throughput Determination of Sleep Duration in Rodents
Published on: April 18, 2018
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Self-Reported Sleep Duration and Quality and Cardiovascular Disease and Mortality: A Dose-Response Meta-Analysis
Chun Shing Kwok1, Evangelos Kontopantelis2, George Kuligowski3
11 Keele Cardiovascular Research Group Institute for Applied Clinical Science and Centre for Prognosis Research Institute of Primary Care and Health Sciences University of Keele Stoke-on-Trent United Kingdom.
Journal of the American Heart Association
|October 30, 2018
Summary
Sleeping longer than 8 hours is linked to increased mortality and cardiovascular risks. Poor sleep quality also elevates coronary heart disease risk, highlighting the importance of optimal sleep duration.
Area of Science:
- Cardiology
- Sleep Medicine
- Epidemiology
Background:
- Growing evidence links sleep duration and quality to cardiovascular harm and mortality.
- Understanding these associations is crucial for public health and clinical practice.
Purpose of the Study:
- To systematically review and meta-analyze prospective cohort studies on sleep duration/quality and cardiovascular outcomes.
- To evaluate dose-response relationships using linear and nonlinear models.
Main Methods:
- Systematic review and meta-analysis of 74 prospective cohort studies (3,340,684 participants).
- Inclusion of studies from MEDLINE and EMBASE databases.
- Application of linear and nonlinear dose-response meta-analysis models, including DerSimonian-Laird random-effects models.
Main Results:
- Sleeping >8 hours was associated with increased all-cause mortality (e.g., 11 hours: RR 1.47).
- Similar patterns observed for stroke and cardiovascular disease mortality.
- Poor sleep quality showed association with coronary heart disease (RR 1.44), but not overall mortality.
Conclusions:
- Deviating from 7-8 hours of sleep increases mortality and cardiovascular event risk.
- Longer sleep durations appear more strongly associated with adverse outcomes than shorter durations.
- Optimal sleep duration is critical for cardiovascular health.
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