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Multimodal Analytical Platform on a Multiplexed Surface Plasmon Resonance Imaging Chip for the Analysis of Extracellular Vesicle Subsets
Published on: March 17, 2023
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Nitride-Based Microarray Biochips: A New Route of Plasmonic Imaging.
Fan-Ching Chien, Jen-Long Lo, Xingwang Zhang
1Research Center for Applied Sciences , Academia Sinica , Taipei 11529 , Taiwan.
ACS Applied Materials & Interfaces
|October 30, 2018
Summary
Researchers developed a compact biosensor using gain-assisted surface plasmon resonance imaging (SPRi) with InGaN quantum wells. This innovation simplifies optical components for enhanced personal health and emergency diagnostics.
Area of Science:
- Biomedical Engineering
- Optoelectronics
- Nanotechnology
Background:
- Biosensing technologies are crucial for improving human lives, with a growing demand for compact devices for personal health and emergency use.
- Surface plasmon resonance imaging (SPRi) offers multiplexed assay capabilities but faces challenges in miniaturization due to complex optical requirements.
- Existing SPRi designs often rely on bulky components like prisms and polarizers, hindering their application in portable settings.
Purpose of the Study:
- To develop a significantly miniaturized Surface Plasmon Resonance Imaging (SPRi) biosensor.
- To explore a novel detection scheme that eliminates complex optical components.
- To maintain or improve sensor performance while achieving a compact form factor.
Main Methods:
- Developed a gain-assisted SPRi system utilizing Indium Gallium Nitride (InGaN) quantum wells (QWs).
- Leveraged the coupling efficiency between QWs and surface plasmons, which is sensitive to localized refractive index variations around analytes.
- Eliminated the need for prisms, polarizers, and beam-tracking elements typical of the Kretschmann configuration.
Main Results:
- Successfully demonstrated a significantly slimmed architecture for SPRi devices.
- Visualized varied local density of states around analytes, enabling detection.
- Achieved high-performance SPRi without compromising sensitivity or speed, despite the simplified optical setup.
Conclusions:
- The developed gain-assisted SPRi with InGaN QWs offers a promising pathway towards highly compact and efficient biosensing platforms.
- This novel modality overcomes the miniaturization limitations of traditional SPRi, paving the way for practical applications in point-of-care diagnostics.
- The simplified optical design enhances the potential for widespread adoption in personal health management and emergency response scenarios.
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