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Published on: February 16, 2018
Synthesis of Benzoindolizines through 1,5-Electrocyclization/Oxidation Cascades
Si-Wei Liu1, Ying-Juan Gao1, Yin Shi1
1Laboratory of Asymmetric Synthesis , Chongqing University of Arts and Sciences , 319 Honghe Avenue , Yongchuan, Chongqing , 402160 , China.
Abstract:
This study presents a convenient synthesis of pyrrolo[1,2- a]quinolines and pyrrolo[2,1- a]isoquinolines with simple quinolines or isoquinolines and Morita-Baylis-Hillman carbonates in the presence of copper acetate. A range of functionalized benzoindolizines could be assembled through an SN2'/deprotonation/1,5-electrocyclization/oxidation cascade pathway in a one-step process.
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