5-fu for problematic scarring: a review of the literature

Keloids and hypertrophic scars represent a common complaint for plastic surgeons. These scars often leave patients with severe morbidity due to their resistance to therapy. A variety of therapeutic options exist, yet none seem to offer a permanent solution, and scars frequently reoccur. The antineoplastic drug 5-fluorouracil (5-FU) has been shown to inhibit fibroblast proliferation in vitro and has been used as a treatment modality for these pathologic and problematic scars. We present a review of literature on treatment protocols, and on the efficacy and safety profile of this drug in the treatment of problematic scarring in terms of size reduction and symptom resolution. Current evidence suggests that 5-FU is effective in treating keloids and hypertrophic scars, but further research must be done to correlate therapeutic response with the age of the scar. In addition, larger randomized control trials must be conducted with longer follow up periods to assess recurrence rates with better accuracy.