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Natural Killer NK and CAR-NK Cell Expansion Method using Membrane Bound-IL-21-Modified B Cell Line
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[Nasal NK/T-cell lymphoma: about two rare cases]
Najoua Bouayad1, Naoual Oubelkacem2, Wafaa Bono2
1Service de Radiothérapie, CHU Hassan II-Fès, Maroc.
The Pan African Medical Journal
|October 31, 2018
Summary
Nasal NK/T-cell lymphoma is a rare, aggressive cancer. Radiotherapy alone may be preferred over combined chemotherapy and radiotherapy for localized stages, despite the disease
Area of Science:
- Oncology
- Hematology
- Pathology
Background:
- NK/T-cell lymphoma is a rare and severe hematologic malignancy.
- This lymphoma predominantly affects the nasal cavity and is more prevalent in certain geographic regions.
Observation:
- Two elderly patients presented with bilateral nasal obstruction and purulent rhinorrhea.
- Clinical examination revealed cleft palate, a potential indicator of the disease.
Findings:
- Diagnosis was confirmed via immunohistochemical examination of biopsies.
- While both patients received CHOEP chemotherapy and radiotherapy, advanced stages showed no survival benefit from combined treatment versus radiotherapy alone.
Implications:
- Radiotherapy alone is considered the treatment of choice, particularly for localized stages of nasal NK/T-cell lymphoma.
- The study highlights the aggressive nature and poor prognosis of this lymphoma, emphasizing the need for accurate diagnosis and tailored treatment strategies.
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