Related Experiment Video
Updated: Feb 3, 2026

Hollow Microneedle-based Sensor for Multiplexed Transdermal Electrochemical Sensing
Published on: June 1, 2012
Rational Design of Ni(OH)2 Hollow Porous Architecture for High-Sensitivity Enzyme-Free Glucose Sensor
Liangliang Tian1, Gege He1,2, Meijing Chen3
1Research Institute for New Materials Technology, Chongqing University of Arts and Sciences, Chongqing, People's Republic of China.
Abstract:
Ni(OH)2 electrocatalysts have acquired lots of research attentions as ideal substitutes for noble metals. However, their electrocatalytic performance still cannot meet the demands for applications due to the difficulties in electron transfer and mass transport. According to kinetics principle, the construction of hollow structure is regarded as an effective method to achieve outstanding electrocatalytic performance. In this work, Ni(OH)2 hollow porous architecture (Ni(OH)2 HPA) was simply synthesized through a coordinating etching and precipitating (CEP) method for the building of enzymatic-free glucose sensors. Ni(OH)2 HPA presents large specific surface area (SSA), ordered diffusion channels, and structure stability. As a detection electrode for glucose, Ni(OH)2 HPA exhibits eminent electroactivity in terms of high sensitivity (1843 μA mM-1 cm-2), lower detection limit (0.23 μM), and short response time (1.4 s). The results demonstrate that Ni(OH)2 HPA has practical applications for construction of enzymatic-free electrochemical sensors. The design of hollow structure also provides an effective engineering method for high-performance sensors.
Related Concept Videos
Rationalizing Substitutions
Rational Expressions
Enzymes
Enzyme deficiencies can often translate into life-threatening diseases. For example, a genetic abnormality resulting in the deficiency of the enzyme G6PD...
Thin-Walled Hollow Shafts
Asymptotes in Rational Functions
Enzyme Kinetics
Scientists typically study enzyme kinetics with a fixed amount of enzyme in the controlled environment of a test tube. When more reactant, or substrate, is...

