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Peptide Nanomaterials Designed from Natural Supramolecular Systems
Hiroshi Inaba1,2, Kazunori Matsuura1,2
1Department of Chemistry and Biotechnology, Graduate School of Engineering, Tottori University, Koyama-Minami 4-101, Tottori, 680-8552, Japan.
Chemical Record (New York, N.Y.)
|October 31, 2018
Summary
Researchers are creating advanced bio-nanomaterials using peptides inspired by natural structures. These peptide-based nanomaterials, including artificial viral capsids and nanofibers, offer new design principles for biomaterials.
Area of Science:
- Biomaterials Science
- Nanotechnology
- Molecular Biology
Background:
- Natural supramolecular assemblies possess evolved, unique properties.
- Bio-nanomaterials utilize peptides, proteins, and nucleic acids.
- Peptides offer optimized structural and functional domains from natural proteins.
Purpose of the Study:
- To summarize progress in peptide-based nanomaterial construction.
- To highlight designs inspired by natural supramolecular systems.
- To explore new design principles for bio-nanomaterials.
Main Methods:
- Isolating and optimizing peptide subunits from natural assemblies.
- Conjugating peptide subunits with exogenous molecules (peptides, proteins, nucleic acids, nanoparticles).
- Designing nanomaterials based on natural supramolecular systems.
Main Results:
- Construction of artificial viral capsids using peptide components.
- Development of self-assembled peptide nanofibers.
- Identification of peptide-based protein-binding motifs.
Conclusions:
- Peptide-based nanomaterials offer versatile platforms for advanced functions.
- Designs inspired by natural supramolecular systems provide effective bio-nanomaterial strategies.
- This approach yields new design principles for bio-nanomaterials.
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