Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Lineage Commitment01:21

Lineage Commitment

4.4K
Commitment is the  process whereby stem cells:
4.4K
Cellular Differentiation00:57

Cellular Differentiation

5.3K
How does a complex organism such as a human develop from a single cell? It all starts from a single fertilized egg which gives rise to a vast array of cell types, such as nerve cells, muscle cells, and epithelial cells that characterize the adult? Throughout development and adulthood, cellular differentiation leads cells to assume their final morphology and physiology. Differentiation is the process by which unspecialized cells become specialized to carry out distinct functions.
A zygote is a...
5.3K
Cellular Respiration01:18

Cellular Respiration

2.0K
Cellular respiration is a crucial metabolic process through which cells obtain energy from organic substances, mainly glucose, to produce adenosine triphosphate (ATP). This process includes the oxidation of substrates and the transfer of electrons to a separate electron acceptor, facilitating ATP synthesis through a sequence of biochemical reactions.Glycolysis: The Initial StepGlycolysis is the first stage of cellular respiration, occurring in the cytoplasm of both prokaryotic and eukaryotic...
2.0K
Genetic Screens02:46

Genetic Screens

5.7K
Genetic screens are tools used to identify genes and mutations responsible for phenotypes of interest. Genetic screens help identify individuals or a group of people at risk of developing  genetic diseases and help them with early intervention, targeted therapy, and reproductive options.
Forward genetic screens
Forward or “classical” genetic screens involve creating random mutations in an organism’s DNA using radiation, mutagens, or insertion of additional bases, which...
5.7K
Introduction to Cellular Respiration01:22

Introduction to Cellular Respiration

189.2K
Organisms harvest energy from food, but this energy cannot be directly used by cells. Cells convert the energy stored in nutrients into a more usable form: adenosine triphosphate (ATP).
ATP stores energy in chemical bonds that can be quickly released when needed. Cells produce energy in the form of ATP through the process of cellular respiration. Although much of the energy from cellular respiration is released as heat, some of it is used to make ATP.
During cellular respiration, several...
189.2K
Cellular Membranes and Drug Transport01:24

Cellular Membranes and Drug Transport

1.5K
Drugs must traverse multiple biological barriers, such as multi-layered skin, single-layered intestinal epithelium, and the plasma membrane, to reach their target sites within the body. The plasma membrane, a highly structured composite of phospholipids, carbohydrates, and proteins, is the cell's protective boundary, facilitating selective substance exchange.
Phospholipids arrange themselves into a bilayer, with hydrophilic heads oriented outward and hydrophobic tails facing inward.
1.5K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

POINTseq: Cell-type-specific barcoding reveals single-cell projection architecture of the mouse dopaminergic system.

Neuron·2026
Same author

BARseq3: a modular system for integrating spatial multi-omics and cellular barcoding in single cells.

bioRxiv : the preprint server for biology·2026
Same author

Specific expansion of motor cortical projections in a singing mouse.

Nature·2026
Same author

MAPseq2: a sensitive barcoded connectomics method.

bioRxiv : the preprint server for biology·2026
Same author

Cell type-specific barcoding reveals the single-neuron projectional architecture of the mouse midbrain dopaminergic system.

bioRxiv : the preprint server for biology·2026
Same author

Synaptic connectomics by sequencing.

Nature methods·2026
Same journal

RNAbpFlow: base pair-augmented SE(3) flow matching for conditional RNA 3D structure generation.

Nature methods·2026
Same journal

Spatio-DARLIN enables robust and efficient in situ lineage tracing in mice at single-cell resolution.

Nature methods·2026
Same journal

EasyGrid: a versatile platform for automated cryo-EM sample preparation and quality control.

Nature methods·2026
Same journal

Cloud-based microscope enables live neuroimaging for 24 h and beyond with worldwide access.

Nature methods·2026
Same journal

Deep molecular profiling in three dimensions.

Nature methods·2026
Same journal

3D pathology-guided microdissection.

Nature methods·2026
See all related articles

Related Experiment Video

Updated: Feb 3, 2026

Competitive Genomic Screens of Barcoded Yeast Libraries
11:59

Competitive Genomic Screens of Barcoded Yeast Libraries

Published on: August 11, 2011

18.8K

Cellular barcoding: lineage tracing, screening and beyond.

Justus M Kebschull1,2, Anthony M Zador3

  • 1Watson School of Biological Sciences, Cold Spring Harbor, NY, USA.

Nature Methods
|November 1, 2018
PubMed
Summary
This summary is machine-generated.

Cellular barcoding uses unique DNA sequences to track millions of cells, advancing developmental biology and gene function studies. This powerful technique is expanding into new fields like neuroanatomy and cellular activity recording.

More Related Videos

Lineage Tracing of Inducible Fluorescently-Labeled Stem Cells in the Adult Mouse Brain
09:44

Lineage Tracing of Inducible Fluorescently-Labeled Stem Cells in the Adult Mouse Brain

Published on: May 20, 2022

3.6K
A Method for Lineage Tracing of Corneal Cells Using Multi-color Fluorescent Reporter Mice
07:48

A Method for Lineage Tracing of Corneal Cells Using Multi-color Fluorescent Reporter Mice

Published on: December 18, 2015

18.1K

Related Experiment Videos

Last Updated: Feb 3, 2026

Competitive Genomic Screens of Barcoded Yeast Libraries
11:59

Competitive Genomic Screens of Barcoded Yeast Libraries

Published on: August 11, 2011

18.8K
Lineage Tracing of Inducible Fluorescently-Labeled Stem Cells in the Adult Mouse Brain
09:44

Lineage Tracing of Inducible Fluorescently-Labeled Stem Cells in the Adult Mouse Brain

Published on: May 20, 2022

3.6K
A Method for Lineage Tracing of Corneal Cells Using Multi-color Fluorescent Reporter Mice
07:48

A Method for Lineage Tracing of Corneal Cells Using Multi-color Fluorescent Reporter Mice

Published on: December 18, 2015

18.1K

Area of Science:

  • Molecular Biology
  • Systems Biology
  • Genomics

Background:

  • Cellular barcoding involves labeling individual cells with unique nucleic acid sequences (barcodes) for tracking.
  • It enables parallel tracking of millions of cells, making it efficient for studying cell populations.
  • Established applications include fate mapping, lineage tracing, and high-throughput screening.

Purpose of the Study:

  • To review the fundamental principles of cellular barcoding, including its mathematical underpinnings.
  • To discuss the diverse applications of cellular barcoding in established and emerging scientific fields.
  • To highlight the impact of decreasing sequencing costs and synthetic biology on barcoding advancements.

Main Methods:

  • Review of existing literature on cellular barcoding techniques and applications.
  • Discussion of the core principles and mathematical models underlying cellular barcoding.
  • Exploration of case studies demonstrating barcoding in developmental biology, gene function, neuroanatomy, and cellular activity recording.

Main Results:

  • Cellular barcoding has provided critical insights into developmental biology and gene function over 25 years.
  • The technique's efficiency in tracking large cell numbers facilitates the study of cellular heterogeneity.
  • Advancements in sequencing technology and synthetic biology are driving the expansion of barcoding applications.

Conclusions:

  • Cellular barcoding is a versatile tool with a significant impact on biological research.
  • Its principles and applications are continuously evolving, offering new avenues for scientific discovery.
  • The integration of barcoding with other technologies promises further breakthroughs in understanding complex biological systems.