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Anticancer Efficacy of Photodynamic Therapy with Lung Cancer-Targeted Nanoparticles
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[Aryl-hydrocarbon receptor as a potential target for anticancer therapy]

J E Vorontsova1, R O Cherezov1, B A Kuzin1

  • 1Koltzov Institute of Developmental Biology of Russian Academy of Sciences, Moscow, Russia.

Biomeditsinskaia Khimiia
|November 1, 2018
PubMed

Insights

The aryl-hydrocarbon receptor (AHR) is involved in cancer development and may be a therapeutic target. AHR ligands show potential in preclinical models for treating difficult cancers.

Area of Science:

  • Molecular Biology
  • Oncology
  • Pharmacology

Background:

  • The aryl-hydrocarbon receptor (AHR) is a transcription factor regulating detoxification, inflammation, and tissue homeostasis.
  • AHR signaling is increasingly implicated in carcinogenesis, with elevated AHR expression found in various tumors.
  • Some anticancer drugs contain AHR ligands, suggesting a role in cancer therapy.

Purpose of the Study:

  • To review the role of AHR in cancer.
  • To explore AHR as a potential therapeutic target for anticancer therapy, particularly for challenging cancers.
  • To discuss the effects of AHR ligands on tumor cell cultures and preclinical cancer models.

Main Methods:

  • Literature review of AHR functions in carcinogenesis.
  • Analysis of AHR expression in tumor types and cell lines.
  • Discussion of preclinical data on AHR ligands in cancer models.

Main Results:

  • AHR plays a significant role in cancer development.
  • AHR is overexpressed in multiple cancer types.
  • AHR ligands demonstrate effects on tumor cells and in animal models.

Conclusions:

  • The aryl-hydrocarbon receptor is a promising target for novel anticancer therapies.
  • Targeting AHR may offer new treatment strategies for cancers with limited options.
  • Further research into AHR ligands is warranted for clinical application in oncology.
Keywords:
anticancer therapyaryl-hydrocarbon receptor AHRcell cultureligandsoncology

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