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Large-Scale Multi-Omics Genome-Wide Association Studies Mo-GWAS: Guidelines for Sample Preparation and Normalization
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Genome wide association study on feed conversion ratio using imputed sequence data in chickens.
Jiaying Wang1, Xiaolong Yuan1, Shaopan Ye1
1Guangdong Provincial Key Lab of Agro-Animal Genomics and Molecular Breeding, College of Animal Science, South China Agricultural University, Guangzhou, 510642, China.
Asian-Australasian Journal of Animal Sciences
|November 2, 2018
Summary
This study identified ten candidate genes linked to feed conversion ratio (FCR) in Chinese indigenous chickens using genome-wide association studies (GWAS). These findings offer insights into the genetic basis of feed efficiency for improved poultry breeding programs.
Area of Science:
- Animal Genetics
- Poultry Science
- Genomics
Background:
- Feed consumption is a major cost in poultry production.
- Understanding the genetic basis of feed efficiency is crucial for improving poultry farming.
- Feed conversion ratio (FCR) is a key indicator of feed efficiency.
Purpose of the Study:
- To identify candidate genes associated with feed conversion ratio (FCR) in Chinese indigenous chickens.
- To utilize genome-wide association study (GWAS) with imputed sequence data for gene discovery.
- To enhance understanding of the molecular determinants of feed efficiency in poultry.
Main Methods:
- Phenotyping 435 Chinese indigenous chickens for FCR.
- Genotyping using a 600K SNP array and imputation to whole-genome sequence data.
- Performing genome-wide association studies (GWAS) using GEMMA software.
Main Results:
- Identified ten significant genomic regions associated with FCR.
- Annotated ten candidate genes, including USP44, LTA4H, and ETS.
- Located several candidate genes within or near previously reported FCR quantitative trait loci (QTL).
Conclusions:
- The study provides valuable genetic information for chicken breeding programs.
- Identified candidate genes contribute to understanding the molecular mechanisms of feeding traits.
- Findings support the genetic improvement of feed efficiency in poultry.
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