[Dawn of Cancer Clinical Sequencing in Chiba University Hospital]

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Masayuki Kano1, Hideaki Miyauchi, Kazuyuki Matsushita

  • 1Dept. of Frontier Surgery, Graduate School of Medicine, Chiba University.

Gan to Kagaku Ryoho. Cancer & Chemotherapy
|November 2, 2018
PubMed

Insights

Cancer genome medicine in Japan is advancing with molecular targeted drugs and next-generation sequencing (NGS). A clinical biobank system supports this progress, aiming for personalized cancer treatments.

Area of Science:

  • Genomics and Precision Medicine
  • Oncology
  • Biotechnology

Background:

  • Genome medicine, particularly in cancer treatment, is gaining significant attention in Japan.
  • Molecular targeted drugs, guided by somatic mutations, are increasingly used in clinical practice.
  • Next-generation sequencing (NGS) enables cost-effective identification of multiple cancer somatic mutations.

Purpose of the Study:

  • To explore the current landscape and future potential of cancer genome medicine in Japan.
  • To highlight the integration of molecular targeted therapies with genomic profiling.
  • To discuss the establishment of a clinical biobank system to support future cancer research.

Main Methods:

  • Analysis of clinical implementation of molecular targeted drugs based on cancer type.
  • Evaluation of next-generation sequencing (NGS) for identifying cancer somatic mutations.
  • Description of the establishment and quality control of a clinical biobank system.

Main Results:

  • While molecular targeted therapies and NGS are advancing, their clinical impact in Japan is still developing.
  • Drug approvals based on cancer genome analysis are being adopted in Japan, mirroring US practices.
  • A robust clinical biobank system with standardized procedures was established in 2011.

Conclusions:

  • Japan is preparing for the era of cancer genome medicine through initiatives like clinical biobanks.
  • Cooperative research with commercial corporations is being initiated to advance the field.
  • Despite current limitations, the infrastructure for personalized cancer treatment is being built.

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