Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

[Endomorphines in schizophrenia].

J L Gilbert

    Biomedicine & Pharmacotherapy = Biomedecine & Pharmacotherapie
    |January 1, 1987
    PubMed
    Summary
    This summary is machine-generated.

    Research into endomorphines in schizophrenia is inconclusive due to varied measurement methods and inconsistent clinical trial results. While some patient subgroups show positive responses, the endorphin system's role in schizophrenia remains unconfirmed.

    Related Concept Videos

    You might also read

    Related Articles

    Articles linked to this work by shared authors, journal, and citation graph.

    Sort by
    Same author

    Meeting of the Northeastern Indiana Medical Society.

    Medical examiner (Chicago, Ill.)·2023
    Same author

    Pseudoplasticity and setting properties of two-solution bone cement containing poly(methyl methacrylate) microspheres and nanospheres for kyphoplasty and vertebroplasty.

    Journal of biomedical materials research. Part B, Applied biomaterials·2009
    Same author

    Giant Cell Arteritis in AJ Americans.

    Journal of clinical rheumatology : practical reports on rheumatic & musculoskeletal diseases·2008
    Same author

    Hot compaction of poly(methyl methacrylate) composites based on fiber shrinkage results.

    Journal of materials science. Materials in medicine·2005
    Same author

    Analysis of the shelf life of a two-solution bone cement.

    Biomaterials·2005
    Same author

    The effect of processing temperature and time on the structure and fracture characteristics of self-reinforced composite poly(methyl methacrylate).

    Journal of materials science. Materials in medicine·2004
    Same journal

    Tumor microenvironment-mediated interactions between macrophages and cancer cells define immunoregulatory transcriptional programs.

    Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie·2026
    Same journal

    Photocontrol of zebrafish behavior with a photoswitchable ligand of nicotinic acetylcholine receptors.

    Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie·2026
    Same journal

    Corrigendum to "Ruyiping extract reduces lung metastasis in triple negative breast cancer by regulating macrophage polarization" [Biomed. Pharmacother. 141 (2021) 111883].

    Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie·2026
    Same journal

    Microfluidic human liver slices reveal antifibrotic effects of liraglutide via HSC deactivation and ECM remodeling.

    Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie·2026
    Same journal

    Corrigendum to "Targeting PD-L1 and disrupting Siglec-9 cooperatively potentiate macrophage phagocytosis of breast cancer via a trispecific macrophage engager (TriME)" [Biomed. Pharmacother. 200 (2026), 119609].

    Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie·2026
    Same journal

    Targeted attenuation of liver fibrosis using microbubble-enhanced protease-activated receptor 1 chimeric antigen receptor T cells.

    Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie·2026
    See all related articles

    Area of Science:

    • Neuroscience
    • Psychiatry
    • Biochemistry

    Background:

    • Schizophrenia's complex etiology has prompted research into endogenous opioids (endomorphines).
    • Previous studies suggest potential links between the endorphin system and schizophrenia, but evidence remains limited.
    • Diverse methodologies in measuring cerebrospinal fluid (CSF) opiate peptides hinder statistical analysis and consensus.

    Purpose of the Study:

    • To evaluate the role of endomorphines in the pathophysiology and symptomatology of schizophrenia.
    • To analyze the impact of opiate receptor agonists and antagonists in schizophrenic patients.

    Main Methods:

    • Review of existing studies on endomorphine levels in CSF of schizophrenia patients.
    • Analysis of clinical trial data for opiate receptor modulators in schizophrenia treatment.

    Related Experiment Videos

    Main Results:

    • Inconsistent findings regarding endomorphine levels in schizophrenia due to methodological variations.
    • Clinical trials highlight the biochemical heterogeneity of schizophrenia patients.
    • No definitive confirmation of the endorphin system's involvement in schizophrenia's origin or symptoms.

    Conclusions:

    • The precise role of the endorphin system in schizophrenia remains unclear.
    • Heterogeneity among schizophrenic patients necessitates subgroup analysis for treatment development.
    • Positive responses in specific subgroups offer hope for future therapeutic advancements, despite current uncertainties.