Related Experiment Video

Updated: Feb 3, 2026

Live Imaging to Study Microtubule Dynamic Instability in Taxane-resistant Breast Cancers
06:02

Live Imaging to Study Microtubule Dynamic Instability in Taxane-resistant Breast Cancers

Published on: February 20, 2017

8.0K

Hunt for the tipping point during endocrine resistance process in breast cancer by dynamic network biomarkers

Rui Liu1, Jinzeng Wang2,3, Masao Ukai4,5

  • 1School of Mathematics, South China University of Science and Technology, Guangzhou, China.

Journal of Molecular Cell Biology
|November 2, 2018
PubMed

Insights

This study introduces a dynamic network biomarker (DNB) method to identify the tipping point for endocrine resistance in cancer. DNB genes were found to be crucial in developing drug resistance and predicting poor patient survival.

Area of Science:

  • Oncology
  • Systems Biology
  • Genomics

Background:

  • Acquired drug resistance is a primary cause of cancer therapy failure.
  • Identifying the onset and molecular drivers of endocrine resistance remains challenging.

Purpose of the Study:

  • To apply the dynamic network biomarker (DNB) method to quantitatively identify the tipping point of endocrine resistance.
  • To detect key molecules and genes associated with the development of drug resistance.

Main Methods:

  • Analysis of time-course mRNA sequencing data from tamoxifen-treated MCF-7 cells.
  • Application of the dynamic network biomarker (DNB) method to identify tipping points and key genes.
  • Survival analysis using clinical datasets to validate DNB gene associations.

Main Results:

  • Identified the tipping point of endocrine resistance and associated leading molecules in ER-positive breast cancer cells.
  • Revealed an interplay between gene mutations and DNB genes in driving transcriptional changes and resistance.
  • Validated DNB genes as predictors of poor survival in breast cancer patients.

Conclusions:

  • The DNB method can detect pre-resistance states and early signs of endocrine resistance.
  • This predictive approach may improve treatment scheduling for drug-resistant cancers.
  • Understanding DNB genes offers insights into mechanisms of acquired drug resistance.
Keywords:
breast cancerdrug resistancedynamic network biomarker (DNB)mRNA-seqmolecular networktipping point

More Related Videos

Performing Data Mining And Integrative Analysis Of Biomarker in Breast Cancer Using Multiple Publicly Accessible Databases07:41

Performing Data Mining And Integrative Analysis Of Biomarker in Breast Cancer Using Multiple Publicly Accessible Databases

Published on: May 17, 2019

9.6K
Orthotopic Transplantation of Breast Tumors as Preclinical Models for Breast Cancer07:45

Orthotopic Transplantation of Breast Tumors as Preclinical Models for Breast Cancer

Published on: May 18, 2020

7.0K

Related Concept Videos

Endocrine Signaling01:45

Endocrine Signaling

Endocrine cells produce hormones to communicate with remote target cells found in other organs. The hormone reaches these distant areas using the circulatory system. This exposes the whole organism to the hormone but only those cells expressing hormone receptors or target cells are affected. Thus, endocrine signaling induces slow responses from its target cells but these effects also last longer.
68.1K
Treatment Resistant Cancers02:56

Treatment Resistant Cancers

Cancer is the second leading cause of death in the United States. A cancer cell is genetically unstable and hence can mutate faster. They can also modify their microenvironment and escape immune surveillance. The difficulties in treating cancer are further compounded by the emergence of rapid resistance to anticancer drugs. The most common ways to attain resistance in cancer cells include alteration in drug transport and metabolism, modification of drug target, elevated DNA damage response, or...
3.8K
What is the Endocrine System?00:46

What is the Endocrine System?

The endocrine system sends hormones—chemical signals—through the bloodstream to target cells—the cells the hormones selectively affect. These signals are produced in endocrine cells, secreted into the extracellular fluid, and then diffuse into the blood. Eventually, they diffuse out of the blood and bind to target cells which have specialized receptors to recognize the hormones.
420.5K
The Endocrine System01:29

The Endocrine System

The endocrine system is an extensive network of glands – organs or tissues in the body that create chemicals that control many bodily functions, that secrete hormones, which are chemical messengers that play essential roles in regulating various bodily functions. These hormones are secreted into the bloodstream and travel throughout the body. They require specific receptors to convey signals to cells possessing these corresponding receptors. This complex signaling mechanism ensures that...
1.4K
An Overview of the Endocrine System01:10

An Overview of the Endocrine System

The endocrine system, a complex network of glands, orchestrates physiological balance within the body through the production and secretion of hormones. These hormones are chemical messengers in intercellular communication, acting as conduits between the secretory cells and distant target sites. They traverse the circulatory system by being released into the extracellular fluid, and their impact is specific to cells possessing receptors for a particular hormone.
The endocrine system collaborates...
14.1K
Structures of the Endocrine System00:59

Structures of the Endocrine System

The intricate framework of the endocrine system encompasses a diverse array of glands, with their target tissues and organs strategically distributed throughout the body. Central to this network are the endocrine glands, specialized structures that lack ducts and release hormones directly into the interstitial fluid. Notably, the hypothalamus, a vital neuroendocrine organ situated in the brain, governs neural functions and serves as a potent source of hormonal regulation. Near the hypothalamus...
12.1K