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[FIBROBLAST ACTIVATION PROTEIN (FAP) AS A POSSIBLE TARGET OF THE ANTITUMOR STRATEGY.]

V V Pleshkan, I V Alekseenko, D V Tyulkina

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    Summary
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    Fibroblast activation protein (FAP), a key component of tumor stroma, is a promising target for cancer therapy. Targeting FAP offers a versatile approach to developing novel tumor treatments by exploiting its unique presence in cancer tissues.

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    Area of Science:

    • Oncology
    • Cancer Biology
    • Molecular Medicine

    Background:

    • Tumors are coevolutionary systems involving a microenvironment with reactive stroma.
    • Cancer-associated fibroblasts (CAFs) are key stromal components, expressing fibroblast activation protein (FAP).
    • FAP is a serine proteinase with dipeptidyl peptidase and endopeptidase activity, found in over 90% of tumors but absent in normal tissues.

    Purpose of the Study:

    • To review the therapeutic potential of targeting fibroblast activation protein (FAP) in cancer.
    • To discuss approaches for modulating cancer-associated fibroblasts (CAFs) by targeting FAP.
    • To explore the advantages of using FAP as a versatile therapeutic target in tumor treatment.

    Main Methods:

    • Literature review of studies on fibroblast activation protein (FAP) and cancer-associated fibroblasts (CAFs).
    • Analysis of FAP's role in tumor microenvironment and its selective expression in neoplastic and embryonic tissues.
    • Discussion of therapeutic strategies targeting FAP and its proteolytic activity.

    Main Results:

    • Fibroblast activation protein (FAP) is highly expressed in cancer-associated fibroblasts (CAFs) across various tumor types.
    • FAP's selective expression in tumor tissues, compared to normal tissues, makes it an attractive therapeutic target.
    • The proteolytic activity of FAP can be leveraged for targeted drug delivery and therapeutic interventions.

    Conclusions:

    • Fibroblast activation protein (FAP) represents a versatile and selective target for innovative cancer therapies.
    • Targeting FAP offers a promising strategy for developing novel treatments against a wide range of tumors.
    • Further research into FAP-targeted therapies holds potential for significant advancements in oncology.