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Case Study: Absorption of Testosterone Cream via Scrotal Delivery
Shawn Needham1, Shane Needham2
1Moses Lake Professional Pharmacy, Moses Lake, Washington. shawnneedham@mlrx.com.
International Journal of Pharmaceutical Compounding
|November 2, 2018
Summary
Transdermal testosterone cream effectively treats low testosterone symptoms. Scrotal application rapidly achieves and sustains therapeutic levels, resolving patient symptoms without side effects.
Area of Science:
- Endocrinology
- Pharmacokinetics
Background:
- Transdermal testosterone therapy is a common treatment for hypogonadism.
- Clinical monitoring typically assesses serum testosterone levels but lacks detailed pharmacokinetic data from multiple time points.
Observation:
- This case study investigates testosterone absorption following scrotal application of a transdermal cream.
- Blood serum concentrations were measured at multiple time points post-application.
Findings:
- Therapeutic testosterone levels (1204.7 ng/dL) were achieved within two hours of scrotal application.
- Sustained therapeutic concentrations (1320.6 ng/dL) were observed beyond six hours.
- This study provides novel pharmacokinetic data on transdermal testosterone delivery via scrotal application.
Implications:
- Transdermal testosterone via scrotal delivery is an effective method for achieving and maintaining therapeutic testosterone concentrations.
- This delivery route offers a promising option for testosterone replacement therapy, potentially improving patient outcomes.
- Resolution of hypogonadal symptoms without adverse effects highlights the efficacy and safety of this approach.
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