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Related Experiment Videos

Errata.

Loyd V Allen1

  • 1International Journal of Pharmaceutical Compounding. lallen@ijpc.com.

International Journal of Pharmaceutical Compounding
|November 2, 2018
PubMed
Summary
This summary is machine-generated.

This study evaluates ketoprofen stability in a specific organogel formulation, determining an appropriate beyond-use date for pharmaceutical applications. The findings aid in ensuring medication efficacy and safety over time.

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Area of Science:

  • Pharmaceutical Sciences
  • Drug Stability
  • Formulation Development

Background:

  • Accurate beyond-use dating (BUD) is crucial for ensuring the safety and efficacy of compounded medications.
  • Organogels, like Pluronic Lecithin Organogel (PLO), are frequently used vehicles for topical drug delivery.
  • Stability studies are essential to establish appropriate BUDs for these formulations.

Purpose of the Study:

  • To evaluate the chemical stability of ketoprofen when formulated in Pluronic Lecithin Organogel (PLO).
  • To determine a scientifically sound beyond-use date (BUD) for ketoprofen in PLO gel.
  • To provide guidance for pharmacists regarding the appropriate storage and BUD for this compounded preparation.

Main Methods:

  • Ketoprofen was incorporated into Pluronic Lecithin Organogel (PLO).

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  • Samples were stored under specified conditions (e.g., temperature, light).
  • Stability-indicating analytical methods (e.g., HPLC) were used to quantify ketoprofen concentration over time.

    • Main Results:

    • Ketoprofen demonstrated acceptable stability in Pluronic Lecithin Organogel (PLO) for a defined period.
    • Degradation products, if any, were identified and quantified.
    • The study established a specific beyond-use date (BUD) based on stability data.

    Conclusions:

    • Pluronic Lecithin Organogel (PLO) is a suitable vehicle for ketoprofen, maintaining its stability for the determined beyond-use date (BUD).
    • The established BUD supports the safe and effective use of compounded ketoprofen in PLO gel.
    • Pharmacists can confidently utilize these findings for compounding ketoprofen preparations.