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Updated: Feb 3, 2026

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The Use of Microbiome Restoration Therapeutics to Eliminate Intestinal Colonization With Multidrug-Resistant

Srinivasa Nithin Gopalsamy1, Michael H Woodworth2, Tiffany Wang1

  • 1Emory University School of Medicine, Atlanta, Georgia.

The American Journal of the Medical Sciences
|November 3, 2018
PubMed

Insights

Fecal microbiota transplantation shows promise in reducing antibiotic resistance by restoring gut microbial diversity and decolonizing multidrug-resistant organisms. Further clinical trials are needed to confirm its safety and efficacy.

Area of Science:

  • Microbiology
  • Public Health
  • Genetics

Background:

  • Antibiotic resistance (AR) is a major global health threat driven by widespread antibiotic use.
  • The intestinal tract harbors multidrug-resistant organisms (MDROs), contributing to the spread of AR.
  • Understanding the resistome through next-generation sequencing is crucial for combating AR.

Purpose of the Study:

  • To review the efficacy of fecal microbiota transplantation (FMT) in decolonizing MDROs.
  • To explore potential mechanisms by which FMT can reduce AR genes.
  • To assess the current evidence for FMT as a strategy against antibiotic resistance.

Main Methods:

  • Literature review of studies on fecal microbiota transplantation for decolonization.
  • Analysis of evidence supporting FMT's role in reducing antibiotic resistance genes.
  • Examination of potential mechanisms of action for FMT in the context of AR.

Main Results:

  • Fecal microbiota transplantation demonstrates potential in eradicating MDROs from the intestinal tract.
  • FMT may restore healthy microbial diversity, a key factor in combating AR.
  • Early evidence suggests FMT can reduce the burden of AR genes.

Conclusions:

  • Fecal microbiota transplantation shows promise as a strategy to combat antibiotic resistance.
  • Further clinical trials are essential to establish the safety and efficacy of FMT for decolonization and AR reduction.
  • FMT may offer a novel approach to managing the growing threat of antibiotic resistance.
Keywords:
Fecal microbiota transplantationIntestinal microbiotaMultidrug-resistant organismsSequencing

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