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Updated: Feb 3, 2026
09:18
A Gut-on-a-Chip Model to Study the Gut Microbiome-Nervous System Axis
Published on: July 28, 2023
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Microbiome-microglia connections via the gut-brain axis
Reem Abdel-Haq1, Johannes C M Schlachetzki2, Christopher K Glass2
1Division of Biology and Biological Engineering, California Institute of Technology, Pasadena, CA rabdelha@caltech.edu.
The Journal of Experimental Medicine
|November 3, 2018
Summary
The gut microbiome influences brain immune cell function, impacting neurodevelopmental and neurodegenerative diseases. Research explores microbial treatments for brain disorders via gut-brain axis communication.
Area of Science:
- Neuroscience
- Immunology
- Microbiology
Background:
- Microglia are brain immune cells crucial for neural function and disease.
- Microglial dysfunction is linked to neurodevelopmental and neurodegenerative diseases.
- Factors influencing microglial activity, including gut signals, are not fully understood.
Purpose of the Study:
- To review the role of the gut microbiome in microglial development and function.
- To explore the gut-brain axis in neurological disease pathogenesis.
- To highlight potential microbial therapies for brain disorders.
Main Methods:
- Review of preclinical and clinical studies on gut microbiome and microglia.
- Analysis of research on gut-brain axis communication.
- Synthesis of findings related to microglial function in homeostatic and disease states.
Main Results:
- The gut microbiome significantly regulates microglial maturation and function.
- Altered gut microbial composition is associated with neurological disorders.
- Bidirectional gut-brain communication influences disease progression.
Conclusions:
- The gut microbiome is a key modulator of microglial activity in the brain.
- Targeting the gut microbiome offers potential therapeutic strategies for neurological diseases.
- Further research is needed to develop novel microbial treatments for brain disorders.
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