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Anatomically Inspired Three-dimensional Micro-tissue Engineered Neural Networks for Nervous System Reconstruction, Modulation, and Modeling
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Molecular memory of cell fate: A missing dimension of neural implant biocompatibility

Ming Fa Michaelangelo Xie1, Rakshaan Rajeev Tebak2, Anagh Pathak3

  • 1School of Computer Science, Carnegie Mellon University , Pittsburgh, PA, USA.

The Journal of Experimental Medicine
|August 14, 2026
PubMed

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Determination01:51

Determination

During embryogenesis, cells become progressively committed to different fates through a two-step process: specification followed by determination. Specification is demonstrated by removing a segment of an early embryo, “neutrally” culturing the tissue in vitro—for example, in a petri dish with simple medium—and then observing the derivatives. If the cultured region gives rise to cell types that it would normally generate in the embryo, this means that it is specified. In contrast, determination...