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Related Experiment Videos

Valproate: It's Effects on Hair.

Anil Kakunje1, Ashwini Prabhu2, E S Sindhu Priya2

  • 1Department of Psychiatry, Yenepoya Medical College, Yenepoya University, Mangalore, Karnataka, India.

International Journal of Trichology
|November 3, 2018
PubMed
Summary

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Valproate medication can cause hair loss, including diffused, nonscarring, and dose-related hair thinning. Topical valproic acid, however, shows early promise for hair regeneration, highlighting the drug

Area of Science:

  • Pharmacology
  • Dermatology
  • Clinical Medicine

Background:

  • Valproate is widely prescribed for seizure disorders, bipolar disorder, and migraine prophylaxis.
  • Common adverse effects include tremor, weight gain, gastrointestinal issues, liver dysfunction, metabolic acidosis, thrombocytopenia, and hair loss.
  • Cosmetically significant side effects like hair loss require recognition to ensure patient compliance.

Purpose of the Study:

  • To review the literature on valproate-induced hair loss and other hair-related adverse events.
  • To explore the contrasting effects of oral valproate and topical valproic acid on hair.
  • To emphasize the clinical importance of understanding valproate's impact on hair.

Main Methods:

  • Conducted an internet search using keywords "valproate" and "hair" on Google Scholar and PubMed.
Keywords:
Hair losshairhair regenerationvalproate

Related Experiment Videos

  • Reviewed articles focusing on valproate's effects on hair and scalp.

    • Main Results:

    • Valproate-induced hair loss is typically diffused, nonscarring, and dose-dependent.
    • Other reported hair issues include curling, graying, altered texture, and a "dirty" appearance.
    • Preliminary research suggests topical valproic acid may promote hair regeneration, contrasting with oral administration's hair loss effects.

    Conclusions:

    • Valproate has significant and varied effects on hair, necessitating clinical awareness.
    • Understanding these effects is crucial for managing patient compliance and treatment outcomes.
    • Further research into topical valproic acid for hair regeneration warrants investigation.