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Updated: Feb 3, 2026

Light-driven Enzymatic Decarboxylation
Published on: May 22, 2016
Transition-Metal-Free Decarboxylative Arylation of 2-Picolinic Acids with Arenes under Air Conditions
Xitao Zhang1, Xiujuan Feng1, Chuancheng Zhou1
1State Key Laboratory of Fine Chemicals , Dalian University of Technology , Dalian 116023 , Liaoning , China.
Abstract:
A facile, transition-metal-free, and direct decarboxylative arylation of 2-picolinic acids with simple arenes is described. The oxidative decarboxylative arylation of 2-picolinic acids with arenes proceeds readily via N-chloro carbene intermediates to afford 2-arylpyridines in satisfactory to good yields under transition-metal-free conditions. This new type of decarboxylative arylation is operationally simple and scalable and exhibits high functional-group tolerance. Various synthetically useful functional groups, such as halogen atoms, methoxycarbonyl, and nitro, remain intact during the decarboxylative arylation of 2-picolinic acids.
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