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[IgE and cellular immunity in cutaneous lymphomas (author's transl)]
Annales De Dermatologie Et De Venereologie
|August 1, 1977
Summary
Elevated serum immunoglobulin E (IgE) levels are common in patients with mycosis fungoides and other lymphomas, often indicating impaired cellular immunity. Mycosis fungoides showed the most significant IgE increase in this study.
Area of Science:
- Immunology
- Dermatology
- Oncology
Context:
- Mycosis fungoides (MF) and Sézary syndrome (SS) are cutaneous T-cell lymphomas.
- Abnormalities in immunoglobulin E (IgE) and cellular immunity are observed in various lymphoproliferative disorders.
Purpose:
- To investigate serum IgE levels and cellular immunity in patients with mycosis fungoides and other lymphomas.
- To compare these levels with those in healthy controls.
Summary:
- Serum IgE levels were measured in 21 lymphoma patients (14 MF/pre-MF, 7 other lymphomas) and 1,019 controls.
- Elevated IgE (≥500 IU/ml) was found in 57% of patients versus 8.1% of controls, with the highest levels in MF.
- Cellular immunity impairment (e.g., negative skin tests, low T-lymphocyte rosettes, reduced mitogen response) was noted in some patients.
Impact:
- Findings suggest a strong association between elevated IgE and cutaneous T-cell lymphomas, particularly mycosis fungoides.
- The study highlights potential immune dysregulation in these conditions.
- Results may aid in understanding disease mechanisms and identifying potential biomarkers.