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Synthesis and characterization of poly(N-isopropylacrylamide-co-acrylamide) mesoglobule core-silica shell
Ngoc-Hanh Cao-Luu1, Quoc-Thai Pham1, Zong-Han Yao2
1Department of Chemical Engineering, National Taiwan University of Science and Technology, Taipei, Taiwan.
Hypothesis:
How to encapsulate poly(N-isopropylacrylamide) (PNIPAM) mesoglobule cores by silica shells greatly affects the resultant nanoparticle structures. Incorporation of acrylamide (AM) unit into PNIPAM in combination with 3-glycidyloxypropyltrimethoxysilane (GLYMO, as a coupling agent) effectively induces nucleation and growth of silica on PNIPAM core surfaces, where the -NH2 of acrylamide reacts with the epoxide of GLYMO while GLYMO further participates in subsequent sol-gel reaction of tetraethyl orthosilicate (TEOS), thereby leading to desirable particle morphology.
Experiments:
PNIPAM-based core-silica shell nanoparticles were prepared by sol-gel reaction of TEOS and GLYMO in the presence of polymeric core particles. The major parameters investigated in a systematic fashion include acrylamide concentration and weight ratio of polymer:GLYMO:TEOS. GPC, DLS, DSC, FE-SEM, TEM, FTIR and TGA were then used to characterize polymeric cores and hybrid nanoparticles.
Findings:
The particle morphology was governed primarily by the acrylamide content and the weight ratio of PNIPAM/AM:GLYMO:TEOS, and desirable hybrid nanoparticles with narrow particle size distribution were achieved. The LCST of PNIPAM-based mesoglobules increases with increasing acrylamide content. Encapsulation of PNIPAM-based mesoglobules with silica also reduces their thermo-sensitivity. This is the first report of developing a novel approach to prepare PNIPAM-based mesoglobule core-silica shell nanoparticles with controllable particle morphologies.
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