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What is pharmacoepidemiology? Definition, methods, interest and clinical applications
Jean-Louis Montastruc1, Justine Benevent1, François Montastruc1
1Service de Pharmacologie Médicale et Clinique, Faculté de Médecine, Centre de Pharmacovigilance, de Pharmacoépidémiologie et d'Informations sur le Médicament, UMR INSERM 1027, CIC INSERM 1436, Faculté de Médecine, Centre Hospitalier Universitaire, 31000 Toulouse, France.
Abstract:
Clinical evaluation of drugs before approval is based on the experimental design of clinical trial with randomization of drug exposure. Unfortunately, conclusions of clinical trials are necessarily limited to patients included into the trials. It is thus necessary to compare these experimental data coming from clinical trials with the real use of drugs in clinical practice. Pharmacoepidemiology is the study of interactions between drugs and human populations, investigating, in real conditions of life, benefits, risks and use of drugs. Pharmacoepidemiology applies to drugs the methods and/or reasoning of both pharmacology and epidemiology. The development of pharmacoepidemiology should improve the "rational drug use".
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