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Interactions with and Membrane Permeabilization of Brain Mitochondria by Amyloid Fibrils
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Repulsive interaction induces fibril formation and their growth

Suparna Khatun1, Kumari Shikha2, Agneyo Ganguly3

  • 1Biophysics Laboratory, Department of Physics, Indian Institute of Technology, Kharagpur 721302, India.

International Journal of Biological Macromolecules
|November 4, 2018
PubMed
Summary

Type-II diabetes involves amylin protein misfolding into amyloid fibrils. We observed protein interactions shift from repulsive to attractive, driving fibril formation and growth, revealing key aggregation mechanisms.

Keywords:
Amylin proteinSecond virial-coefficient (A(2))TEM

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