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Articles linked to this work by shared authors, journal, and citation graph.

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Loss of β-adrenergic-stimulated phosphorylation of CaV1.2 channels on Ser1700 leads to heart failure.

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Targeting cAMP/PKA pathway for glycemic control and type 2 diabetes therapy.

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Expression of a dominant negative PKA mutation in the kidney elicits a diabetes insipidus phenotype.

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Selective expression of a dominant-negative type Iα PKA regulatory subunit in striatal medium spiny neurons impairs gene expression and leads to reduced feeding and locomotor activity.

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Deficiency of the RIIβ subunit of PKA affects locomotor activity and energy homeostasis in distinct neuronal populations.

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Updated: Feb 3, 2026

Author Spotlight: Advancing Real-Time cAMP Detection in Cells Using cADDis Biosensor
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Neuronal cAMP/PKA Signaling and Energy Homeostasis.

Linghai Yang1

  • 1Department of Pharmacology, University of Washington, Seattle, WA, USA. linghai@uw.edu.

Advances in Experimental Medicine and Biology
|November 4, 2018
PubMed
Summary

The brain regulates body weight and glucose using the cAMP/protein kinase A (PKA) pathway. This pathway influences feeding, energy expenditure, and glucose balance through neuronal signaling.

Area of Science:

  • Neuroscience
  • Metabolic Regulation
  • Cellular Signaling

Background:

  • The brain is central to maintaining energy and glucose homeostasis.
  • Peripheral signals are integrated by the brain to elicit metabolic and behavioral responses.
  • The cAMP/protein kinase A (PKA) pathway is a key intracellular signaling cascade downstream of G-protein-coupled receptors (GPCRs).

Purpose of the Study:

  • To summarize recent genetic and pharmacological findings on the role of cAMP/PKA signaling in the brain.
  • To elucidate the brain's mechanisms for regulating body weight and glucose metabolism via cAMP/PKA.
  • To highlight the involvement of neuronal cAMP/PKA activity in feeding and energy expenditure.

Main Methods:

  • Review of recent genetic studies.
Keywords:
Body weightBrainGPCRMetabolism

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  • Analysis of pharmacological studies.
  • Integration of findings on neuronal signaling pathways.

    • Main Results:

    • Neuronal cAMP/PKA activity is implicated in regulating feeding behaviors.
    • Brain cAMP/PKA signaling influences energy expenditure.
    • The pathway is crucial for maintaining glucose homeostasis.

    Conclusions:

    • The cAMP/PKA pathway in the brain is a significant regulator of body weight and glucose metabolism.
    • Understanding this pathway offers insights into metabolic disorders.
    • Targeting brain cAMP/PKA signaling may present therapeutic strategies.