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Biomarker-driven and molecularly targeted therapies for pancreatic adenocarcinoma

David B Zhen1, Andrew Coveler1, Silvia Zanon2

  • 1Division of Medical Oncology, Department of Medicine, University of Washington, Fred Hutchinson Cancer Research Center, Seattle, WA, USA.

Seminars in Oncology
|November 5, 2018
PubMed

Insights

Pancreatic ductal adenocarcinoma (PDAC) is a deadly cancer. Advances in understanding molecular changes offer new biomarker-driven therapies, including immune checkpoint inhibitors and PARP inhibitors, improving treatment strategies.

Area of Science:

  • Oncology
  • Molecular Biology
  • Genetics

Background:

  • Pancreatic ductal adenocarcinoma (PDAC) presents a significant challenge due to limited effective treatments.
  • Recent advancements have elucidated key molecular alterations driving PDAC.
  • Identifying these alterations is crucial for developing targeted therapies.

Purpose of the Study:

  • To review the major biological mechanisms underlying PDAC.
  • To discuss current and future directions for molecularly targeted therapies in PDAC.
  • To highlight the impact of biomarker-driven therapeutic strategies.

Main Methods:

  • Literature review of molecular mechanisms in PDAC.
  • Analysis of current and emerging targeted therapies.
  • Evaluation of biomarker-driven treatment successes.

Main Results:

  • Significant progress has been made in understanding PDAC molecular landscape.
  • Biomarker-driven therapies, such as immune checkpoint inhibitors and PARP inhibitors, show promise.
  • Targeting hyaluronan with PEGPH20 is effective in specific patient populations.

Conclusions:

  • Molecular insights are paving the way for more effective PDAC treatments.
  • Biomarker-guided therapies represent a critical advancement in managing PDAC.
  • Future research should focus on further refining molecularly targeted approaches for PDAC.
Keywords:
Immune therapiesMolecular targeted therapiesPancreatic cancerSignaling pathwaysTumor stroma

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