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Updated: Feb 3, 2026
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The Application of 1% Methylene Blue Dye As a Single Technique in Breast Cancer Sentinel Node Biopsy
Published on: June 1, 2019
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Sentinel node for malignant melanoma: An observational study of a consecutive single centre experience
Valerio Belgrano1, Dimitrios Katsarelias1, Jan Mattsson1
1Department of Surgery, Institute of Clinical Sciences, Sahlgrenska Academy at the University of Gothenburg, Sahlgrenska University Hospital, Gothenburg, Sweden.
Summary
Sentinel node biopsy (SNB) for melanoma provides prognostic information. Breslow thickness predicts positive sentinel nodes, while SN status, tumor thickness, and ulceration are key prognostic factors for melanoma-specific survival.
Area of Science:
- Oncology
- Surgical Pathology
- Dermatology
Background:
- Sentinel node biopsy (SNB) is crucial for melanoma staging and prognosis.
- The accuracy and prognostic value of SNB depend on various factors.
- Understanding these factors is essential for optimizing patient outcomes.
Purpose of the Study:
- To evaluate outcome data following the implementation of SNB for melanoma.
- To analyze the false negative rate (FNR) and factors predicting sentinel node (SN) positivity.
- To identify prognostic factors for melanoma-specific survival (MSS).
Main Methods:
- Retrospective observational study of 769 melanoma patients undergoing SNB.
- Data collected from a prospectively maintained database (March 2000 - December 2013).
- Analysis included FNR, SN positivity predictors, and MSS prognostic factors, with a median follow-up of 55 months.
Main Results:
- The overall FNR was 20%, with a decreasing trend over time.
- Breslow thickness was the sole independent predictor of SN positivity.
- Melanoma-specific survival was significantly influenced by SN status, Breslow thickness, and ulceration.
Conclusions:
- Breslow thickness is the primary predictor for positive sentinel nodes in melanoma.
- SN status, Breslow thickness, and ulceration are independent prognostic factors for MSS.
- Tumor burden in SNs, using a 1 mm cutoff, did not significantly impact survival outcomes.
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