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Updated: Feb 3, 2026

A Porcine Model of Acute Autologous Pulmonary Embolism
Published on: September 6, 2024
Cardiac arrest due to pulmonary embolism
Abdullah Ebrahim Laher1, Guy Richards2
1Department of Emergency Medicine, Faculty of Health Sciences, University of the Witwatersrand, 7 Jubilee Road, Parktown, Johannesburg, 2193, South Africa; Department of Critical Care, Faculty of Health Sciences, University of the Witwatersrand, 7 Jubilee Road, Parktown, Johannesburg, 2193, South Africa.
Massive pulmonary embolism (PE) can be fatal, especially with cardiac arrest. Prompt thrombolysis and other treatments, despite limited evidence, may improve survival in suspected PE cardiac arrest cases.
Area of Science:
- Emergency Medicine
- Cardiology
- Pulmonology
Background:
- Pulmonary embolism (PE) presents non-specifically and is a life-threatening condition.
- Massive PE carries a 30% mortality rate, escalating to 95% with cardiac arrest.
- Outcomes for PE with cardiac arrest are typically poor.
Purpose of the Study:
- To review the limited evidence and case reports on managing suspected pulmonary embolism in patients experiencing cardiac arrest.
- To emphasize the importance of timely intervention in suspected PE with cardiac arrest.
Main Methods:
- Review of published case reports and small studies on thrombolysis and other therapies for PE in cardiac arrest.
- Analysis of outcomes associated with interventions in this critical patient population.
Main Results:
- Thrombolysis and other interventions have shown promising outcomes in select case reports.
- Despite a lack of randomized controlled trials, prompt treatment may be life-saving.
Conclusions:
- Suspected pulmonary embolism in cardiac arrest warrants immediate intervention.
- Thrombolysis and other therapies, while lacking robust trial data, are associated with good outcomes in limited studies and should be considered.
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