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How I approach iron deficiency with and without anemia

Jacquelyn M Powers1,2, Sarah H O'Brien3,4

  • 1Department of Pediatrics, Section of Hematology/Oncology, Baylor College of Medicine, Houston, Texas.

Pediatric Blood & Cancer
|November 6, 2018
PubMed

Insights

Iron deficiency anemia is common in children, especially young ones and adolescent females. New insights into iron regulation and safer treatments offer updated care options for affected pediatric patients.

Area of Science:

  • Pediatric Hematology-Oncology
  • Iron Homeostasis
  • Nutritional Anemia

Background:

  • Iron deficiency anemia (IDA) is a frequent reason for pediatric hematology-oncology referrals.
  • Understanding iron metabolism, including the hormone hepcidin, is crucial for managing IDA.
  • Recent advancements in intravenous iron formulations offer safer treatment options.

Observation:

  • Young children and adolescent females are the most commonly affected demographics.
  • Children with complex medical histories or chronic inflammatory conditions require special attention.
  • Comorbid gastrointestinal disorders can complicate iron absorption and treatment.

Findings:

  • Improved knowledge of iron homeostasis guides current treatment strategies.
  • Clinical trial data from adults and children inform pediatric IDA management.
  • Safer intravenous iron formulations expand therapeutic possibilities.

Implications:

  • Treatment recommendations for pediatric IDA necessitate updated considerations.
  • Personalized approaches are needed for children with complex health issues.
  • Further research may optimize the use of novel iron therapies in pediatric populations.

Keywords:
hepcidininflammationintravenousnutritionaltherapy

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