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Related Experiment Video

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Choroidal morphology under pachydrusen.

Jiwon Baek1, Jae Hyung Lee2, Byung-Joo Chung2

  • 1Department of Ophthalmology and Visual Science, Bucheon St. Mary's Hospital, College of Medicine, The Catholic University of Korea, Gyeonggi-do, South Korea.

Clinical & Experimental Ophthalmology
|November 6, 2018
PubMed
Summary

Pachydrusen, unique to pachychoroid disorders, exhibit distinct choroidal morphology. These findings reveal increased Haller's layer thickness and correlate pachydrusen locations with underlying pachyvessels.

Keywords:
choroidal morphologypachychoroidpachydrusenpachyvessel

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Area of Science:

  • Ophthalmology
  • Choroidal Imaging
  • Retinal Diseases

Background:

  • Pachydrusen differ from conventional drusen in pachychoroid disorders.
  • This study investigates the choroidal morphology beneath pachydrusen.

Purpose of the Study:

  • To analyze the specific choroidal morphological profiles under pachydrusen.
  • To understand the relationship between pachydrusen and choroidal structure in pachychoroid diseases.

Main Methods:

  • Cross-sectional case series involving 136 eyes with pachydrusen.
  • Utilized color fundus photography and swept-source optical coherence tomography (OCT) for analysis.
  • Examined choroidal morphology using OCT B-scans and en face imaging.

Main Results:

  • Analyzed 225 pachydrusen, with most located para- or perifoveally.
  • Found a higher proportion of Haller's layer to total choroidal thickness under pachydrusen compared to the subfovea (P < 0.001).
  • 90.1% of pachydrusen correlated topographically with underlying dilated Haller vessels (pachyvessels).

Conclusions:

  • Choroidal morphology under pachydrusen shows increased Haller's layer thickness and an attenuated choriocapillaris.
  • This morphology is characteristic of pachychoroid definition.
  • Pachydrusen locations are topographically linked to underlying pachyvessels.