Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Peripheral neuropathy associated with Crohn's disease.

R Nemni, R Fazio, M Corbo

    Neurology
    |August 1, 1987
    PubMed
    Summary

    Peripheral neuropathy can occur in Crohn's disease patients without vitamin B12 deficiency or metronidazole use. This study identifies a potential new association between Crohn's disease and nerve damage.

    Related Concept Videos

    You might also read

    Related Articles

    Articles linked to this work by shared authors, journal, and citation graph.

    Sort by
    Same author

    Mitoxantrone prior to interferon beta-1b in aggressive relapsing multiple sclerosis: a 3-year randomised trial.

    Journal of neurology, neurosurgery, and psychiatry·2011
    Same author

    Voxelwise assessment of the regional distribution of damage in the brains of patients with multiple sclerosis and fatigue.

    AJNR. American journal of neuroradiology·2011
    Same author

    Thalamic damage predicts the evolution of primary-progressive multiple sclerosis at 5 years.

    AJNR. American journal of neuroradiology·2011
    Same author

    Cortical lesions in children with multiple sclerosis.

    Neurology·2011
    Same author

    Sensorimotor functional connectivity changes in amyotrophic lateral sclerosis.

    Cerebral cortex (New York, N.Y. : 1991)·2011
    Same author

    A randomized, double-blind, placebo-controlled, parallel-group, enriched-design study of nabiximols* (Sativex(®) ), as add-on therapy, in subjects with refractory spasticity caused by multiple sclerosis.

    European journal of neurology·2011

    Area of Science:

    • Neurology
    • Gastroenterology
    • Clinical Medicine

    Background:

    • Peripheral neuropathy is a known complication of Crohn's disease, typically linked to vitamin B12 deficiency or metronidazole.
    • The exact mechanisms and other potential causes of neuropathy in Crohn's disease remain under investigation.

    Purpose of the Study:

    • To report and investigate the association between Crohn's disease and peripheral neuropathy in patients without the commonly identified risk factors.
    • To explore the underlying mechanism of nerve damage in these cases.

    Main Methods:

    • Case report of two patients with Crohn's disease and peripheral neuropathy.
    • Clinical evaluation, including neurological examination and cerebrospinal fluid (CSF) analysis.
    • Assessment of nerve damage mechanism through clinical presentation and disease course.

    Related Experiment Videos

    Main Results:

    • Two patients with Crohn's disease developed peripheral neuropathy unrelated to vitamin B12 deficiency or metronidazole.
    • Both patients experienced predominantly sensory distal neuropathy, with symptoms correlating to their Crohn's disease activity.
    • Cerebrospinal fluid analysis was normal in both patients.
    • Axonal degeneration was identified as the mechanism of nerve damage.

    Conclusions:

    • Crohn's disease may be associated with peripheral neuropathy through mechanisms other than vitamin B12 deficiency or metronidazole.
    • The neuropathy appears to be primarily sensory and involves axonal degeneration.
    • Further research is needed to elucidate the specific pathogenic pathways linking Crohn's disease to neuropathy in these cases.