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12β-Acetyloxyperforatin, a New Limonoid from Harrisonia Perforata
Peng-Yan Gui1,2, Xiao-Hui Yan3,2, Wen-Juan Yuan2,4
1a Key Laboratory of Marine Drugs, Ministry of Education of China, School of Medicine and Pharmacy, Ocean University of China , China.
Natural Product Research
|November 6, 2018
Abstract:
A new A, D-seco limonoid, named 12-acetyloxyperforatin (1), along with three known ones, were isolated from the leaves of Harrisonia perforata. Their structures were elucidated on the basis of spectroscopic analysis, including extensive NMR techniques and computational modelling. These compounds showed no inhibitory activity against the 11β-HSD1 enzyme.
