Erdheim Chester disease presented isolated breast and axillary involvement

Area of Science:

• Oncology
• Pathology
• Radiology

Background:

• Erdheim-Chester disease (ECD) is a rare non-Langerhans cell histiocytosis.
• Commonly affects long bones, skin, orbit, pituitary, and retroperitoneal space.
• Isolated breast involvement is exceptionally rare.

Purpose of the Study:

• To report an unusual case of isolated breast involvement of Erdheim-Chester disease.
• To discuss the radiological and histopathological findings in this rare presentation.
• To emphasize ECD in the differential diagnosis of breast lesions.

Main Methods:

• Case report presentation.
• Review of radiological imaging findings.
• Histopathological analysis of breast tissue.

Main Results:

• The case presented with isolated Erdheim-Chester disease of the breast.
• Radiological and histopathological findings confirmed the diagnosis.
• ECD was considered in the differential diagnosis of histiocytoid breast lesions.

Conclusions:

• Erdheim-Chester disease can manifest as isolated breast involvement.
• Radiological and histopathological evaluation is crucial for diagnosis.
• ECD should be included in the differential diagnosis for histiocytoid breast lesions.