Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Stereotype Content Model02:16

Stereotype Content Model

15.4K
The Stereotype Content Model (SCM) was first proposed by Susan Fiske and her colleagues (Fiske, Cuddy, Glick & Xu, 2002; see also Fiske, 2012 and Fiske, 2017). The SCM specifies that when someone encounters a new group, they will stereotype them based on two metrics: warmth—or that group’s perceived intent, and how likely they are to provide help or inflict harm—and competence—or their ability to carry out that objective. Depending on the warmth-competence...
15.4K
Competition02:34

Competition

24.8K
When organisms require the same limited resources within an environment, they may have to compete for them. Competition is a net-negative interaction. Even if two competing individuals or populations do not interact directly, the overall fitness of both competitors is lowered as a result of not having full access to the limited resource.
24.8K
Bacterial Transformation01:33

Bacterial Transformation

59.9K
In 1928, bacteriologist Frederick Griffith worked on a vaccine for pneumonia, which is caused by Streptococcus pneumoniae bacteria. Griffith studied two pneumonia strains in mice: one pathogenic and one non-pathogenic. Only the pathogenic strain killed host mice.
Griffith made an unexpected discovery when he killed the pathogenic strain and mixed its remains with the live, non-pathogenic strain. Not only did the mixture kill host mice, but it also contained living pathogenic bacteria that...
59.9K
Solution Equilibrium and Saturation01:59

Solution Equilibrium and Saturation

21.9K
Imagine adding a small amount of sugar to a glass of water, stirring until all the sugar has dissolved, and then adding a bit more. You can repeat this process until the sugar concentration of the solution reaches its natural limit, a limit determined primarily by the relative strengths of the solute-solute, solute-solvent, and solvent-solvent attractive forces. You can be certain that you have reached this limit because, no matter how long you stir the solution, undissolved sugar remains. The...
21.9K
Stereotypes, Prejudice, and Discrimination02:55

Stereotypes, Prejudice, and Discrimination

95.4K
Humans are very diverse and although we share many similarities, we also have many differences. The social groups we belong to help form our identities (Tajfel, 1974). These differences may be difficult for some people to reconcile, which may lead to prejudice toward people who are different. Prejudice is a negative attitude and feeling toward an individual based solely on one’s membership in a particular social group (Allport, 1954; Brown, 2010). Prejudice is common against people who...
95.4K
Ecological Niches02:02

Ecological Niches

26.6K
All organisms have a position within an ecosystem. The complete set of living and nonliving factors—including food resources, climate, and terrain—that define the position of a given organism are collectively referred to as the organism’s ecological niche.
26.6K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Sarcoidosis and Systemic Comorbidities: Sex-Related Differences in a Multicenter Italian Cohort.

Respiration; international review of thoracic diseases·2026
Same author

Lung transplantation from polytrauma donors: beyond primary graft dysfunction.

Frontiers in medicine·2026
Same author

Factors affecting exercise performance at the 6-min walk test in long-COVID: a multicenter study from Italy.

Internal and emergency medicine·2026
Same author

Adhesion molecules and T cell imbalance in severe eosinophilic asthma: Insights from anti-IL-5R treatment.

Pulmonology·2026
Same author

Bone involvement in sarcoidosis: Insights from a multicentre Italian cohort.

Sarcoidosis, vasculitis, and diffuse lung diseases : official journal of WASOG·2026
Same author

Dyspnea and fatigue in Long-COVID: definition of risk factors and of DLCO-based phenotypes in a multicenter study of 765 patients from Italy.

Respiratory medicine·2026

Related Experiment Video

Updated: Feb 3, 2026

Author Spotlight: Expanding Interventional Pulmonology Research with Robotic-Assisted Bronchoscopy
04:10

Author Spotlight: Expanding Interventional Pulmonology Research with Robotic-Assisted Bronchoscopy

Published on: July 19, 2024

1.3K

Competence in transbronchial cryobiopsy.

Emanuela Barisione1, Mario Salio2, Micaela Romagnoli3

  • 1Unit of Pneumology, San Martino Policlinic Hospital, Genoa, Italy - emabarisione@yahoo.it.

Panminerva Medica
|November 6, 2018
PubMed
Summary

Transbronchial lung cryobiopsy (TBLC) is a safe and effective method for diagnosing diffuse interstitial lung diseases (DILDs). This minimally invasive technique yields larger, artifact-free lung samples compared to traditional biopsies, offering a valuable alternative for patients requiring histopathological data.

More Related Videos

Substernal Thyroid Biopsy Using Endobronchial Ultrasound-guided Transbronchial Needle Aspiration
10:19

Substernal Thyroid Biopsy Using Endobronchial Ultrasound-guided Transbronchial Needle Aspiration

Published on: November 10, 2014

26.3K
An R-Based Landscape Validation of a Competing Risk Model
05:37

An R-Based Landscape Validation of a Competing Risk Model

Published on: September 16, 2022

2.6K

Related Experiment Videos

Last Updated: Feb 3, 2026

Author Spotlight: Expanding Interventional Pulmonology Research with Robotic-Assisted Bronchoscopy
04:10

Author Spotlight: Expanding Interventional Pulmonology Research with Robotic-Assisted Bronchoscopy

Published on: July 19, 2024

1.3K
Substernal Thyroid Biopsy Using Endobronchial Ultrasound-guided Transbronchial Needle Aspiration
10:19

Substernal Thyroid Biopsy Using Endobronchial Ultrasound-guided Transbronchial Needle Aspiration

Published on: November 10, 2014

26.3K
An R-Based Landscape Validation of a Competing Risk Model
05:37

An R-Based Landscape Validation of a Competing Risk Model

Published on: September 16, 2022

2.6K

Area of Science:

  • Pulmonology
  • Interventional Pulmonology
  • Diagnostic Procedures

Background:

  • Transbronchial lung cryobiopsy (TBLC) has emerged as a key diagnostic tool for diffuse interstitial lung diseases (DILDs).
  • Historically, cryobiopsy was used therapeutically for central airway obstruction, but is now adapted for peripheral lung parenchyma sampling.
  • Surgical lung biopsy remains the gold standard for histopathological diagnosis in interstitial lung diseases (ILDs).

Purpose of the Study:

  • To evaluate the role and efficacy of TBLC in the histologic diagnosis of DILDs.
  • To compare TBLC with traditional diagnostic methods for ILDs.
  • To highlight the technical aspects and safety profile of TBLC.

Main Methods:

  • Review of published literature on TBLC for DILD diagnosis.
  • Analysis of specimen size and morphological quality obtained via TBLC.
  • Assessment of the safety and diagnostic yield of TBLC.

Main Results:

  • TBLC provides larger lung parenchymal specimens (3x) than conventional transbronchial biopsies.
  • Specimens obtained via TBLC exhibit unaltered, artifact-free morphology.
  • TBLC demonstrates a good safety profile and appears effective for diagnosing idiopathic pulmonary fibrosis.

Conclusions:

  • TBLC is a feasible, safe, and minimally invasive diagnostic tool for ILDs.
  • Standardization of TBLC technical aspects is crucial for optimal outcomes.
  • TBLC should be integrated into the practice of interventional pulmonologists in specialized centers with a multidisciplinary approach.