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Archival Research

Archival Research

Some researchers gain access to large amounts of data without interacting with a single research participant. Instead, they use existing records to answer various research questions. This type of research approach is known as archival research. Archival research relies on looking at past records or data sets to look for interesting patterns or relationships. For example, a researcher might access the academic records of all individuals who enrolled in college within the past ten years and...

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Cells are regularly exposed to mutagens—factors in the environment that can damage DNA and generate mutations. UV radiation is one of the most common mutagens and is estimated to introduce a significant number of changes in DNA. These include bends or kinks in the structure, which can block DNA replication or transcription. If these errors are not fixed, the damage can cause mutations, which in turn can result in cancer or disease depending on which sequences are...

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Nucleic acids are the most important macromolecules for the continuity of life. They carry the cell's genetic blueprint and have instructions for its functioning. The two main types of nucleic acids are deoxyribonucleic acid (DNA) and ribonucleic acid (RNA).
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DNA is the genetic material in all living organisms, ranging from single-celled bacteria to multicellular mammals. It is in the nucleus of eukaryotes and the organelles such as chloroplasts and mitochondria....

Single Nucleotide Polymorphisms-SNPs

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Related Experiment Video

Updated: Feb 3, 2026

Assessing Intertidal Populations of the Invasive European Green Crab

Assessing Intertidal Populations of the Invasive European Green Crab

Published on: September 16, 2020

The European Nucleotide Archive in 2018.

Peter W Harrison¹, Blaise Alako¹, Clara Amid¹

¹European Molecular Biology Laboratory, European Bioinformatics Institute, Wellcome Genome Campus, Hinxton, Cambridge CB10 1SD, UK.

Nucleic Acids Research

|November 6, 2018

Summary

This summary is machine-generated.

The European Nucleotide Archive (ENA) archives global sequencing data. In 2018, ENA focused on enhancing data coordination, submission processes, validation tools, and improving its retrieval infrastructure for researchers.

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Area of Science:

Bioinformatics
Genomics
Data Archiving

Background:

The European Nucleotide Archive (ENA) has served as a primary repository for public sequencing data for over 30 years.
ENA, provided by EMBL-EBI, plays a crucial role in supporting and accelerating global research efforts through data accessibility.

Purpose of the Study:

To provide an overview of the European Nucleotide Archive's services and content in 2018.
To highlight key development areas and infrastructure improvements undertaken by ENA.

Main Methods:

Review of ENA's existing services and data content as of 2018.
Description of ongoing development initiatives, including data coordination, submission enhancements, and validation tools.
Overview of the transition to a new browser and retrieval infrastructure.

Main Results:

ENA continued to provide comprehensive archiving of global sequencing data.
Development efforts focused on improving data submission workflows and user validation.
Initiated a transition towards a modernized data browser and retrieval system.

Conclusions:

ENA remains a vital resource for the scientific community, committed to data stewardship and accessibility.
Ongoing developments aim to enhance user experience and data management capabilities for genomic research.