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Updated: Feb 3, 2026
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In vivo Imaging of Optic Nerve Fiber Integrity by Contrast-Enhanced MRI in Mice
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Bilateral Acquired Progressive Retinal Nerve Fiber Layer Myelination
Ophthalmic Surgery, Lasers & Imaging Retina
|November 6, 2018
Summary
This case study details acquired progressive myelination of the optic disc in a young patient over 10 years. Multimodal imaging confirmed myelination without other ocular or systemic issues.
Area of Science:
- Ophthalmology
- Neuro-ophthalmology
- Medical Imaging
Background:
- Optic disc myelination is typically congenital and presents at birth.
- Acquired myelination of the optic disc is rare, especially in the absence of underlying pathology.
- Progressive myelination is an even rarer presentation.
Observation:
- A hyperopic adolescent patient was monitored for 10 years.
- Bilateral optic disc myelination was observed to develop progressively.
- Myelination of the left optic disc appeared at age 7, and the right at age 13.
Findings:
- Multimodal imaging, including cross-sectional and en face optical coherence tomography (OCT) angiography, was utilized.
- The imaging confirmed myelination of the retinal nerve fiber layer.
- Other potential causes, such as astrocytic hamartoma, were excluded.
Implications:
- This case expands the understanding of acquired optic disc myelination.
- It highlights the importance of longitudinal follow-up and advanced imaging in diagnosing rare optic nerve conditions.
- Further research may elucidate the mechanisms behind acquired progressive myelination.
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